miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data

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dc.contributor.authorBovolenta, Luiz Augusto [UNESP]
dc.contributor.authorPinhal, Danillo [UNESP]
dc.contributor.authorAcencio, Marcio Luis
dc.contributor.authorOliveira, Arthur Casulli de [UNESP]
dc.contributor.authorMoxon, Simon
dc.contributor.authorMartins, Cesar [UNESP]
dc.contributor.authorLemke, Ney [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAvenue das Hauts-Fourneaux
dc.contributor.institutionUniversity of East Anglia (UEA)
dc.date.accessioned2020-12-12T02:17:04Z
dc.date.available2020-12-12T02:17:04Z
dc.date.issued2020-07-22
dc.description.abstractNile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have focused on the multiple roles played by microRNAs (miRNAs) in the post-transcriptional regulation of protein-coding genes involved in the emergence of phenotypes with relevance for aquaculture. However, there is still a growing demand for a reference resource dedicated to integrating Nile Tilapia miRNA information, obtained from both experimental and in silico approaches, and facilitating the analysis and interpretation of RNA sequencing data. Here, we present an open repository dedicated to Nile Tilapia miRNAs: the miRTil database. The database stores data on 734 mature miRNAs identified in 11 distinct tissues and five key developmental stages. The database provides detailed information about miRNA structure, genomic context, predicted targets, expression profiles, and relative 5p/3p arm usage. Additionally, miRTil also includes a comprehensive pre-computed miRNA-target interaction network containing 4936 targets and 19,580 interactions.en
dc.description.affiliationDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu São Paulo State University-UNESP
dc.description.affiliationDepartment of Chemical and Biological Sciences Institute of Biosciences of Botucatu São Paulo State University-UNESP
dc.description.affiliationLuxembourg Centre for Systems Biomedicine Université du Luxembourg Avenue das Hauts-Fourneaux, Campus Belval
dc.description.affiliationSchool of Biological Sciences University of East Anglia (UEA), Norwich Research Park
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University-UNESP
dc.description.affiliationUnespDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu São Paulo State University-UNESP
dc.description.affiliationUnespDepartment of Chemical and Biological Sciences Institute of Biosciences of Botucatu São Paulo State University-UNESP
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University-UNESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2010/20684-3
dc.description.sponsorshipIdFAPESP: 2011/06465-0
dc.description.sponsorshipIdFAPESP: 2012/13450-1
dc.description.sponsorshipIdFAPESP: 2012/15589-7
dc.description.sponsorshipIdFAPESP: 2013/03644-6
dc.description.sponsorshipIdFAPESP: 2014/08420-1
dc.description.sponsorshipIdFAPESP: 2015/19176-7
dc.identifierhttp://dx.doi.org/10.3390/cells9081752
dc.identifier.citationCells, v. 9, n. 8, 2020.
dc.identifier.doi10.3390/cells9081752
dc.identifier.issn2073-4409
dc.identifier.lattes7977035910952141
dc.identifier.lattes8858800699425352
dc.identifier.orcid0000-0003-3534-974X
dc.identifier.scopus2-s2.0-85088679607
dc.identifier.urihttp://hdl.handle.net/11449/200824
dc.language.isoeng
dc.relation.ispartofCells
dc.sourceScopus
dc.subjectdatabase
dc.subjectmicroRNA
dc.subjectmicroRNA expression profile
dc.subjectmicroRNA target prediction
dc.subjectNile tilapia
dc.subjectpost-transcriptional regulation
dc.titlemiRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Dataen
dc.typeArtigo
unesp.advisor.lattes7977035910952141
unesp.author.lattes8858800699425352[6]
unesp.author.orcid0000-0002-8116-8280[1]
unesp.author.orcid0000-0002-8278-240X[3]
unesp.author.orcid0000-0003-3534-974X[6]

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Artigos - Física e Biofísica - IBB