A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

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dc.contributor.authorPedrolli, Danielle Biscaro [UNESP]
dc.contributor.authorKühm, Christian
dc.contributor.authorSévin, Daniel C.
dc.contributor.authorVockenhuber, Michael P.
dc.contributor.authorSauer, Uwe
dc.contributor.authorSuess, Beatrix
dc.contributor.authorMack, Matthias
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany;
dc.contributor.institutionInstitute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich, Switzerland;
dc.contributor.institutionDepartment of Biology, Technical University Darmstadt, 64287 Darmstadt, Germany.
dc.contributor.institutionDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany; m.mack@hs-mannheim.de.
dc.date.accessioned2015-12-07T15:39:40Z
dc.date.available2015-12-07T15:39:40Z
dc.date.issued2015-10-22
dc.description.abstractFlavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient (high levels), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced turn-off activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.en
dc.description.affiliationDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany; Department of Bioprocess and Biotechnology, School of Pharmaceutical Sciences, Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, Brazil
dc.description.affiliationDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany
dc.description.affiliationInstitute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich, Switzerland
dc.description.affiliationDepartment of Biology, Technical University Darmstadt, 64287 Darmstadt, Germany
dc.description.affiliationDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany
dc.description.affiliationUnespDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany; Department of Bioprocess and Biotechnology, School of Pharmaceutical Sciences, Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, Brazil
dc.format.extent14054–14059
dc.identifierhttp://dx.doi.org/10.1073/pnas.1515024112
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, p. 14054–14059, 2015.
dc.identifier.doi10.1073/pnas.1515024112
dc.identifier.issn1091-6490
dc.identifier.orcid0000-0002-3034-6497
dc.identifier.pubmed26494285
dc.identifier.urihttp://hdl.handle.net/11449/131658
dc.language.isoeng
dc.relation.ispartofProceedings Of The National Academy Of Sciences Of The United States Of America
dc.relation.ispartofsjr6,092
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectBacillus subtilisen
dc.subjectFmn riboswitchen
dc.subjectRibren
dc.subjectFlavin mononucleotideen
dc.subjectRiboflavinen
dc.titleA dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilisen
dc.typeArtigo
unesp.author.orcid0000-0002-3034-6497[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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