Seropositivity for Coxiella burnetii in suspected patients with dengue in São Paulo state, Brazil

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dc.contributor.authorde França, Danilo Alves [UNESP]
dc.contributor.authorMioni, Mateus de Souza Ribeiro [UNESP]
dc.contributor.authorFornazari, Felipe [UNESP]
dc.contributor.authorde Lima Duré, Ana Íris
dc.contributor.authorSilva, Marcos Vinicius Ferreira
dc.contributor.authorPossebon, Fábio Sossai [UNESP]
dc.contributor.authorRichini-Pereira, Virgínia Bodelão
dc.contributor.authorLangoni, Helio [UNESP]
dc.contributor.authorMegid, Jane [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionEzequiel Dias Foundation
dc.contributor.institutionRegional Laboratories Center II
dc.date.accessioned2023-03-02T00:29:18Z
dc.date.available2023-03-02T00:29:18Z
dc.date.issued2022-01-01
dc.description.abstractQ fever and brucellosis are zoonoses that cause fever and other systemic clinical signs in humans; their occurrences are neglected and the differential diagnosis for some diseases is disregarded. This study aimed to investigate the seropositivity for Coxiella burnetii and Bru-cella spp. antibodies in patients suspected of dengue from 38 municipalities in the state of São Paulo, Brazil. The samples (n = 604) were obtained by convenience from the Adolfo Lutz Institute serum bank. Sera were subjected to an indirect immunofluorescence assay (IFA) using in-house and commercial diagnostic protocols to evaluate C. burnetii positivity. For Brucella spp., sera were subjected to rapid plate serum agglutination with buffered acidi-fied antigen (AAT), slow tube serum agglutination (SAL), and 2-mercaptoethanol (2-ME) techniques. Associations and statistical inferences of the results were performed by logistic regression according to the clinical and demographic variables collected from the patients. Statistical analyses were performed using Statistical Analysis Software (SAS) and associations were considered when p value was <0.05. In all, 129 patients showed positive results for Q fever, indicating a seropositivity of 21.4% (95% CI 18.15–24.85). Patients with 14–20 days of symptoms had 2.12 (95% CI 1.34–3.35) times more chances of being seropositive for Q fever than patients with 7–13 days, and patients with 21–27 days of fever had 2.62 (95% CI 1.27–5.41) times more chances of being seropositive for Q fever than patients with 7–13 days. For the other variables analyzed, there were no significant associations between the groups. No positivity for brucellosis was observed. This is the most comprehensive study of people seropositive for Q fever in São Paulo state and provides additional data for the medical community in Brazil. It is suggested that Q fever may be an important differential diagnosis of febrile illnesses in the region, demanding the government’s attention and investment in health.en
dc.description.affiliationDepartment of Veterinary Hygiene and Public Health Paulista State University “Júlio de Mesquita Filho”, São Paulo
dc.description.affiliationOctávio Magalhães Institute Ezequiel Dias Foundation, Minas Gerais
dc.description.affiliationAdolfo Lutz Institute Regional Laboratories Center II, São Paulo
dc.description.affiliationUnespDepartment of Veterinary Hygiene and Public Health Paulista State University “Júlio de Mesquita Filho”, São Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 155904/2019-1
dc.identifierhttp://dx.doi.org/10.1371/journal.pntd.0010392
dc.identifier.citationPLoS Neglected Tropical Diseases, v. 16, n. 5, 2022.
dc.identifier.doi10.1371/journal.pntd.0010392
dc.identifier.issn1935-2735
dc.identifier.issn1935-2727
dc.identifier.scopus2-s2.0-85129853156
dc.identifier.urihttp://hdl.handle.net/11449/241824
dc.language.isoeng
dc.relation.ispartofPLoS Neglected Tropical Diseases
dc.sourceScopus
dc.titleSeropositivity for Coxiella burnetii in suspected patients with dengue in São Paulo state, Brazilen
dc.typeArtigo

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Artigos - Higiene Veterinária e Saúde Pública - FMVZ