Nanotechnology-Based Drug Delivery Systems for Treatment of Tuberculosis-A Review

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dc.contributor.authorSilva, Patricia Bento da [UNESP]
dc.contributor.authorFreitas, Eduardo Sinesio de [UNESP]
dc.contributor.authorBernegossi, Jessica [UNESP]
dc.contributor.authorGoncalez, Maira Lima [UNESP]
dc.contributor.authorSato, Mariana Rillo [UNESP]
dc.contributor.authorFujimura Leite, Clarice Queico [UNESP]
dc.contributor.authorPavan, Fernando Rogerio [UNESP]
dc.contributor.authorChorilli, Marius [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T16:27:50Z
dc.date.available2018-11-26T16:27:50Z
dc.date.issued2016-02-01
dc.description.abstractTuberculosis (TB) is an infectious and transmissible disease that is caused by Mycobacterium tuberculosis and primarily affects the lungs, although it can affect other organs and systems. The pulmonary presentation of TB, in addition to being more frequent, is also the most relevant to public health because it is primarily responsible for the transmission of the disease. The to their low World Health Organization (WHO) recommends a combined therapeutic regimen of several drugs, such as rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA) and ethambutol (ETB). These drugs have low plasma levels after oral administration, due to their low water solubility, poor permeability and ability to be rapidly metabolized by the liver and at high concentrations. Furthermore, they have short t(1/2) (only 1-4 hours) indicating a short residence in the plasma and the need for multiple high doses, which can result in neurotoxicity and hepatotoxicity. Nanotechnology drug delivery systems have considerable potential for the treatment of TB. The systems can also be designed to allow for the sustained release of drugs from the matrix and drug delivery to a specific target. These properties of the systems enable the improvement of the bioavailability of drugs, can reduce the dosage and frequency of administration, and may solve the problem of non-adherence to prescribed therapy, which is a major obstacle to the control of TB. The purpose of this study was to systematically review nanotechnology-based drug delivery systems for the treatment of TB.en
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPROPE
dc.description.sponsorshipIdFAPESP: 2013/09265-7
dc.description.sponsorshipIdFAPESP: 2013/14957-5
dc.description.sponsorshipIdFAPESP: 2012/19568-4
dc.description.sponsorshipIdCNPq: 406827/2012-5
dc.description.sponsorshipIdPROPE: 0102/004/43
dc.format.extent241-260
dc.identifierhttp://dx.doi.org/10.1166/jbn.2016.2149
dc.identifier.citationJournal Of Biomedical Nanotechnology. Valencia: Amer Scientific Publishers, v. 12, n. 2, p. 241-260, 2016.
dc.identifier.doi10.1166/jbn.2016.2149
dc.identifier.issn1550-7033
dc.identifier.urihttp://hdl.handle.net/11449/161268
dc.identifier.wosWOS:000371449400001
dc.language.isoeng
dc.publisherAmer Scientific Publishers
dc.relation.ispartofJournal Of Biomedical Nanotechnology
dc.relation.ispartofsjr0,828
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMycobacterium tuberculosis
dc.subjectTuberculosis
dc.subjectNanotechnology
dc.subjectDrug Delivery Systems
dc.titleNanotechnology-Based Drug Delivery Systems for Treatment of Tuberculosis-A Reviewen
dc.typeResenha
dcterms.rightsHolderAmer Scientific Publishers

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Artigos - Fármacos e Medicamentos - FCFAR
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