Contractile function of fasting and digesting broad-snouted caiman (Caiman latirostris)

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dc.contributor.authorLopes, Andre Guelli [UNESP]
dc.contributor.authorMonteiro, Diana Amaral
dc.contributor.authorVasconcelos, Eliton da Silva [UNESP]
dc.contributor.authorKalinin, Ana Lucia
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T12:01:07Z
dc.date.available2023-07-29T12:01:07Z
dc.date.issued2023-05-17
dc.description.abstractFeeding regimes are a critical process to ensure survival and reproduction, which modulate several behavioral and physiological patterns of ectotherms, especially cardiovascular adjustments. However, crocodilian myocardial contractile function after food intake remains understudied. We investigated the importance of ventricular myocardial contractility during digestion in the broad-snouted caiman, Caiman latirostris Daudin, 1801. Isometric ventricle preparations and Ca2+-handling protein expression were used to investigate the effects of prolonged fasting (30 days) and feeding (48 h after feeding on meals at 15% of body mass) on cardiac function. Upon feeding, there was no significant difference in relative ventricular mass. The cardiac response of the caiman to digestion was characterized by upregulation of the Na+/Ca2+ exchanger expression and an increase in myocardial contractility (positive inotropism and lusitropism) within the physiological range of heart rate. The digesting caiman's ventricular myocardium was able to maintain faster kinetics of contraction and relaxation, allowing for significantly increased cardiac pumping capacity at higher pacing frequencies. Our results demonstrated that the myocardium of broad-snouted caimans exhibits specializations in excitation-contraction coupling, which can provide a means to support high cardiovascular performance during digestion.en
dc.description.affiliationUniv Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Sao Paulo State Univ UNESP, Joint Grad Program Physiol Sci, Araraquara, SP, Brazil
dc.description.affiliationUnespFed Univ Sao Carlos UFSCar, Sao Paulo State Univ UNESP, Joint Grad Program Physiol Sci, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoa de Nível Superior (CAPES)
dc.description.sponsorshipInstituto Nacional de Ciencia e Tecnologia em Fisiologia Comparada (INCT-FisComp)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo de Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdCNPq: 573921/2008-3
dc.description.sponsorshipIdFAPESP: 08/57712-4
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1139/cjz-2022-01801
dc.identifier.citationCanadian Journal of Zoology. Ottawa: Canadian Science Publishing, 9 p., 2023.
dc.identifier.doi10.1139/cjz-2022-01801
dc.identifier.issn0008-4301
dc.identifier.urihttp://hdl.handle.net/11449/245650
dc.identifier.wosWOS:000995717600001
dc.language.isoeng
dc.publisherCanadian Science Publishing
dc.relation.ispartofCanadian Journal Of Zoology
dc.sourceWeb of Science
dc.subjectbroad-snouted caiman
dc.subjectCaiman latirostris
dc.subjectcardiac function
dc.subjectcontractile force
dc.subjectdigestion
dc.subjectNa plus
dc.subjectCa2+exchanger
dc.subjectrelative ventricular mass
dc.titleContractile function of fasting and digesting broad-snouted caiman (Caiman latirostris)en
dc.typeArtigo
dcterms.rightsHolderCanadian Science Publishing

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