Angiotensin II-derived reactive oxygen species underpinning the processing of the cardiovascular reflexes in the medulla oblongata

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dc.contributor.authorBraga, Valdir A.
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorJovita, Mariana G.
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:04Z
dc.date.available2014-05-20T13:46:04Z
dc.date.issued2011-08-01
dc.description.abstractThe brainstem is a major site in the central nervous system involved in the processing of the cardiovascular reflexes such as the baroreflex and the peripheral chemoreflex. The nucleus tractus solitarius and the rostral ventrolateral medulla are 2 important brainstem nuclei, and they play pivotal roles in autonomic cardiovascular regulation. Angiotensin II is one of the neurotransmitters involved in the processing of the cardiovascular reflexes within the brainstem. It is well-known that one of the mechanisms by which angiotensin II exerts its effect is via the activation of pathways that generate reactive oxygen species (ROS). In the central nervous system, ROS are reported to be involved in several pathological diseases such as hypertension, heart failure and sleep apnea. However, little is known about the role of ROS in the processing of the cardiovascular reflexes within the brainstem. The present review mainly discussed some recent findings documenting a role for ROS in the processing of the baroreflex and the peripheral chemoreflex in the brainstem.en
dc.description.affiliationUniversidade Federal da Paraíba (UFPB), Pharmaceut Technol Lab, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil
dc.format.extent269-274
dc.identifierhttp://dx.doi.org/10.1007/s12264-011-1529-z
dc.identifier.citationNeuroscience Bulletin. New York: Springer, v. 27, n. 4, p. 269-274, 2011.
dc.identifier.doi10.1007/s12264-011-1529-z
dc.identifier.issn1673-7067
dc.identifier.lattes4544450092427426
dc.identifier.urihttp://hdl.handle.net/11449/16266
dc.identifier.wosWOS:000295729300006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofNeuroscience Bulletin
dc.relation.ispartofjcr3.155
dc.relation.ispartofsjr1,282
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectangiotensin IIen
dc.subjectsuperoxideen
dc.subjectrostral ventrolateral medullaen
dc.subjectnucleus tractus solitariusen
dc.subjectbaroreflexen
dc.subjectperipheral chemoreflexen
dc.titleAngiotensin II-derived reactive oxygen species underpinning the processing of the cardiovascular reflexes in the medulla oblongataen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes4544450092427426[2]
unesp.author.orcid0000-0002-1395-4036[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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