Pressor, dipsogenic, natriuretic and kaliuretic responses to central carbachol in rats with lesion of the medial septal area

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dc.contributor.authorCleidionice Luiz, Aparecida [UNESP]
dc.contributor.authorAbrão Saad, Wilson [UNESP]
dc.contributor.authorAntonio de Arruda Camargo, Luiz [UNESP]
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorAntonio de Luca Junior, Laurival [UNESP]
dc.contributor.authorVanderlei Menani, José [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:26Z
dc.date.available2014-05-27T11:17:26Z
dc.date.issued1991-11-11
dc.description.abstractIn the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the dipsogenic, natriuretic, kaliuretic and pressor responses elicited by intracerebroventricular (i.c.v.) injection of the cholinergic agonist carbachol. Freely moving rats with sham or MSA lesion (1-7 days and 14-18 days) and a stainless steel cannula implanted into the lateral ventricle were studied. In sham rats, i.c.v. injection of carbachol (7.5 nmol) produced an increase in water intake (10.2 ± 1.5 ml/h), mean arterial pressure (MAP) (35 ± 5 mmHg) and urinary Na+ and K+ excretion (551 ± 83 and 170 ± 17 μEq 120 min, resp.). The pressor (18 ± 3 and 14 ± 4 mmHg, resp.) and natriuretic responses (178 ± 58 and 172 ± 38 μEq 120 min) produced by i.c.v. carbachol in acute or chronic MSA-lesioned rats were reduced. No change was observed in urinary K+ excretion and a reduced water intake (5 ± 1.3 ml/h) was observed only in acute MSA-lesioned rats. These results suggest that the MSA plays an important role for the pressor and natriuretic responses induced by central cholinergic activation in rats. A small influence of this structure on water intake may also be suggested. © 1991.en
dc.description.affiliationDepartment of Physiology School of Dentistry Paulista State University, Araraquara
dc.description.affiliationUnespDepartment of Physiology School of Dentistry Paulista State University, Araraquara
dc.format.extent195-198
dc.identifierhttp://dx.doi.org/10.1016/0304-3940(91)90300-I
dc.identifier.citationNeuroscience Letters, v. 132, n. 2, p. 195-198, 1991.
dc.identifier.doi10.1016/0304-3940(91)90300-I
dc.identifier.issn0304-3940
dc.identifier.lattes6551236936295697
dc.identifier.lattes1023597870118105
dc.identifier.scopus2-s2.0-0026072270
dc.identifier.urihttp://hdl.handle.net/11449/64151
dc.identifier.wosWOS:A1991GR76700014
dc.language.isoeng
dc.relation.ispartofNeuroscience Letters
dc.relation.ispartofjcr2.159
dc.relation.ispartofsjr0,946
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectArterial pressure
dc.subjectCholinergic receptor
dc.subjectFluid balance
dc.subjectSeptal area
dc.subjectSodium excretion
dc.subjectWater intake
dc.subjectcarbachol
dc.subjectanimal experiment
dc.subjectbrain injury
dc.subjectdrinking
dc.subjectkaliuresis
dc.subjectmale
dc.subjectnatriuresis
dc.subjectnonhuman
dc.subjectpressor response
dc.subjectpriority journal
dc.subjectrat
dc.subjectseptum nucleus
dc.subjectAnimal
dc.subjectBlood Pressure
dc.subjectBrain
dc.subjectCarbachol
dc.subjectDrinking
dc.subjectMale
dc.subjectNatriuresis
dc.subjectPotassium
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSeptum Pellucidum
dc.subjectSupport, Non-U.S. Gov't
dc.subjectThirst
dc.subjectUrine
dc.titlePressor, dipsogenic, natriuretic and kaliuretic responses to central carbachol in rats with lesion of the medial septal areaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes6551236936295697
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-8270-2652[5]
unesp.author.orcid0000-0003-1167-4441[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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