Ventilação mecânica de curta duração com altos níveis de O 2 em pulmões de ratos idosos

Página do item simplificado
dc.contributor.authorCavassani, Sâmia Santos
dc.contributor.authorJunqueira, Virginia Berlanga Campos
dc.contributor.authorMoraes, Juliana Britto
dc.contributor.authorLuzo, Karen Kristina
dc.contributor.authorSilva, Claudeny Matos Assis
dc.contributor.authorBarros, Maciel
dc.contributor.authorMarinho, Márcia [UNESP]
dc.contributor.authorSimões, Ricardo Santos
dc.contributor.authorOliveira-Júnior, Itamar Souza
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T22:37:00Z
dc.date.available2022-04-28T22:37:00Z
dc.date.issued2011-04-01
dc.description.abstractPurpose: To evaluate the effects of mechanical ventilation (MV) of high-oxygen concentration in pulmonary dysfunction in adult and elderly rats. Methods: Twenty-eight adult (A) and elderly (E), male rats were ventilated for 1 hour (G-AV1 and G-EV1) or for 3 hours (G-AV3 and G-EV3). A and E groups received a tidal volume of 7 mL/kg, a positive end-expiratory pressure of 5 cm H2O, respiratory rate of 70 cycles per minute, and an inspiratory fraction of oxygen of 1. We evaluated total protein content and malondialdehyde in bronchoalveolar lavages (BAL) and performed lung histomorphometrical analyses. Results: In G-EV1 animals, total protein in BAL was higher (33.0±1.9 μg/mL) compared with G-AV1 (23.0±2.0 μg/mL). Upon 180 minutes of MV, malondialdehyde levels increased in elderly (G-EV3) compared with adult (G-AV3) groups. Malondialdehyde and total proteins in BAL after 3 hours of MV were higher in elderly group than in adults. In G-EV3 group we observed alveolar septa dilatation and signifcative increase in neutrofles number in relation to adult group at 60 and 180 minutes on MV. Conclusion: A higher fraction of inspired oxygen in short courses of mechanical ventilation ameliorates the parameters studied in elderly lungs.en
dc.description.affiliationDepartment of Preventive Medicine UNIFESP, Sao Paulo-SP
dc.description.affiliationDepartment of Biological Science UNIFESP, Diadema-SP
dc.description.affiliationDivision of Anesthesiology, Pain and Intensive Therapy UNIFESP, Sao Paulo-SP
dc.description.affiliationDepartment of Production Support and Animal Health Paulista State University, Araçatuba-SP
dc.description.affiliationDepartment of Morphology and Genetics Histology Division UNIFESP, Sao Paulo-SP
dc.description.affiliationDivision of Geriatrics and Gerontology UNIFESP, Sao Paulo-SP
dc.description.affiliationUnespDepartment of Production Support and Animal Health Paulista State University, Araçatuba-SP
dc.format.extent107-113
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502011000200006
dc.identifier.citationActa Cirurgica Brasileira, v. 26, n. 2, p. 107-113, 2011.
dc.identifier.doi10.1590/S0102-86502011000200006
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.scopus2-s2.0-79953668000
dc.identifier.urihttp://hdl.handle.net/11449/226291
dc.language.isopor
dc.relation.ispartofActa Cirurgica Brasileira
dc.sourceScopus
dc.subjectAging
dc.subjectLung injury
dc.subjectNeutrophil infiltration
dc.subjectOxidative stress
dc.subjectRats
dc.subjectVentilator-induced lung injury
dc.titleVentilação mecânica de curta duração com altos níveis de O 2 em pulmões de ratos idosospt
dc.title.alternativeShort courses of mechanical ventilation with high-O 2 levels in elderly rat lungsen
dc.typeArtigo

Arquivos

Coleções

Artigos - Apoio, Produção e Saúde Animal - FMVA