Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part II: Laboratory aspects, electrocardiogram and histopathology

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dc.contributor.authorNogueira, Rosa Maria Barilli
dc.contributor.authorSakate, M. [UNESP]
dc.contributor.authorSangiorgio, F.
dc.contributor.authorLaposy, C. B.
dc.contributor.authorTostes, R. A.
dc.contributor.institutionUniversity of Western São Paulo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.date.accessioned2014-05-27T11:22:41Z
dc.date.available2014-05-27T11:22:41Z
dc.date.issued2007-12-01
dc.description.abstractThe present work shows laboratory aspects, electrocardiogram and histopathology results during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1mg/kg venom (sc), 50mg antiophidic serum (iv) and fluid therapy including 0.9% NaCl solution (iv); and Group III received 1mg/kg venom (sc), 50mg antiophidic serum (iv) and fluid therapy including 0.9% NaCl solution containing sodium bicarbonate diluted to the dose of 4mEq/kg. Urinalysis showed brown urine, proteinuria, occult blood and myoglobinuria. Respiratory acidosis and hypotension were also observed. At the venom inoculation site, there was discreet edema, popliteal lymph node response, musculature presenting whitish areas and necrotic myositis with myoregenerative activity. There was not evidence of electrocardiographical and biochemical alterations.en
dc.description.affiliationDepartment of Small Animals Medical Clinic University of Western São Paulo, Presidente Prudente, São Paulo State
dc.description.affiliationDepartment of Small Animals School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo State
dc.description.affiliationDepartment of Clinical Pathology UNOESTE, Presidente Prudente, São Paulo State
dc.description.affiliationDepartment of Pathological Anatomy UNOESTE, Presidente Prudente, São Paulo State
dc.description.affiliation, Rua Santo Brugnoli, 249, 19025-160, Presidente Prudente, São Paulo
dc.description.affiliationUnespDepartment of Small Animals School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo State
dc.format.extent811-820
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992007000400011
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 811-820, 2007.
dc.identifier.doi10.1590/S1678-91992007000400011
dc.identifier.file2-s2.0-38349135369.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992007000400011
dc.identifier.scopus2-s2.0-38349135369
dc.identifier.urihttp://hdl.handle.net/11449/70082
dc.identifier.wosWOS:000251325200011
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCrotalus durissus terrificus
dc.subjectDog
dc.subjectHistopathology
dc.subjectLaboratory aspects
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titleExperimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part II: Laboratory aspects, electrocardiogram and histopathologyen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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