Resveratrol for preventing medication-related osteonecrosis of the jaws in rats

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dc.contributor.authorVitale, Marcelo
dc.contributor.authorCorrêa, Mônica Grazieli
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorCirano, Fabiano Ribeiro
dc.contributor.authorRibeiro, Fernanda Vieira
dc.contributor.authorMonteiro, Mabelle Freitas
dc.contributor.authorCasati, Marcio Zaffalon
dc.contributor.authorPimentel, Suzana Peres
dc.contributor.institutionPaulista University
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:46:57Z
dc.date.available2023-07-29T13:46:57Z
dc.date.issued2023-01-01
dc.description.abstractThis study evaluated the effect of resveratrol (RES) on the prevention of medication-related osteonecrosis of the jaws (MRONJ) in ovariectomized (OVX) rats treated with zoledronate (ZOL). Fifty rats were distributed in five groups: SHAM (n = 10): non-ovariectomy + placebo; OVX (n = 10):ovariectomy + placebo; OVX + RES (n = 10):ovariectomy + resveratrol; OVX + ZOL (n = 10):ovariectomy + placebo + zoledronate; and OVX + RES + ZOL (n = 10):ovariectomy + resveratrol + zoledronate. The mandibles left sides were analyzed with micro-CT, histomorphometry, and immunohistochemistry. On the right side, bone markers gene expression was analyzed by qPCR. ZOL increased the percentage of necrotic bone and reduced the neo-formed bone compared to groups not receiving ZOL (p < 0.05). RES impacted the tissue healing pattern in OVX + ZOL + RES, reduced inflammatory cell infiltrate, and improved bone formation in the extraction site. Osteoblasts, alkaline phosphatase (ALP)-, and osteocalcin (OCN)-immunoreactive cells were lower in OVX-ZOL than in SHAM, OVX, and OVX-RES. The OXV-ZOL-RES had fewer osteoblasts and ALP- and OCN-cells than the SHAM and OVX-RES. The tartrate-resistant acid phosphatase (TRAP)-positive cells were reduced in the presence of ZOL (p < 0.05), while the TRAP mRNA levels increased with ZOL treatment, with or without resveratrol, compared with the other groups (p < 0.05). RES alone increased superoxide dismutase levels compared to OVX + ZOL and OVX + ZOL + RES (p < 0.05). In conclusion, resveratrol reduced the tissue impairment severity induced by ZOL; however, it could not prevent the occurrence of MRONJ.en
dc.description.affiliationDental Research Division School of Dentistry Paulista University
dc.description.affiliationDepartment of Basic Sciences Dental School of Araçatuba University Estadual Paulista UNESP
dc.description.affiliationUnespDepartment of Basic Sciences Dental School of Araçatuba University Estadual Paulista UNESP
dc.identifierhttp://dx.doi.org/10.1111/odi.14544
dc.identifier.citationOral Diseases.
dc.identifier.doi10.1111/odi.14544
dc.identifier.issn1601-0825
dc.identifier.issn1354-523X
dc.identifier.scopus2-s2.0-85150598738
dc.identifier.urihttp://hdl.handle.net/11449/248545
dc.language.isoeng
dc.relation.ispartofOral Diseases
dc.sourceScopus
dc.subjectbisphosphonates
dc.subjectosteonecrosis
dc.subjectosteoporosis
dc.subjectovariectomy
dc.subjectresveratrol
dc.subjectzoledronic acid
dc.titleResveratrol for preventing medication-related osteonecrosis of the jaws in ratsen
dc.typeArtigo
unesp.author.orcid0000-0001-9333-4349[6]
unesp.author.orcid0000-0001-9234-0536[7]

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