Heparin, heparin plus ASA and dipyridamole, and arteriovenous fistula as adjuvant methods to prevent rethrombosis after venous thrombectomy. Experimental study in rabbits

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dc.contributor.authorRollo, Hamilton Almeida [UNESP]
dc.contributor.authorMaffei, Francisco Humberto de Abreu [UNESP]
dc.contributor.authorYoshida, Winston Bonetti [UNESP]
dc.contributor.authorLastoria, S.
dc.contributor.authorCuri, P. R.
dc.contributor.authorMattar, L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:25Z
dc.date.available2014-05-27T11:17:25Z
dc.date.issued1991-01-01
dc.description.abstractVenous rethrombosis following thrombectomy is a common event. The aim of the present study was to verify the action of heparin, heparin plus acetyl salicylic acid (ASA) and dipyridamole, and of an arteriovenous fistula (AVF) in the prevention of this complication. Thrombosis was induced in 48 male rabbits by the injection of thrombin in a segment of the left jugular vein, in which the blood flow was arrested for 10 minutes. After 48 hours, the animals were randomly allocated into one of 4 groups of treatment: (1) control, (2) subcutaneous heparin (600 S.I. Units/kg - 8/8 hours), (3) heparin, in the same dose, plus ASA (10 mg/kg/once a day), and dipyridamole (0.5 mg/kg thrice a day), (4) an AVF was surgically constructed between the left carotid after and the left maxillar vein. After 30 minutes, thrombectomy was performed. The venous blood flow, the hematocrit, activated partial thromboplastin time and thrombin time tests were performed before, right after the thrombectomy and 48 hours after thrombectomy. Venography was performed after thrombectomy and at the end of the experiment. The animals were killed 48 hours after thrombectomy and the veins were examined macroscopically. Venous rethrombosis was significantly prevented only in the AVF group (9/12), when compared to control group (0/12), heparin group (1/12) and heparin plus antiaggregating agents group (2/12). These results validate further clinical and experimental investigations with the use of AVF to prevent rethrombosis after venous thrombectomy, when a reduction of venous flow is present.en
dc.format.extent88-94
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/1861092
dc.identifier.citationInternational Angiology, v. 10, n. 2, p. 88-94, 1991.
dc.identifier.issn0392-9590
dc.identifier.lattes8240785779318526
dc.identifier.lattes3613835231654932
dc.identifier.scopus2-s2.0-0025845877
dc.identifier.urihttp://hdl.handle.net/11449/64104
dc.language.isoeng
dc.relation.ispartofInternational Angiology
dc.relation.ispartofjcr1.156
dc.relation.ispartofsjr0,476
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectacetylsalicylic acid
dc.subjectdipyridamole
dc.subjectheparin
dc.subjectanimal model
dc.subjectarteriovenous fistula
dc.subjectintramuscular drug administration
dc.subjectmale
dc.subjectnonhuman
dc.subjectrabbit
dc.subjectsubcutaneous drug administration
dc.subjectthrombectomy
dc.subjectthrombosis prevention
dc.subjectvein thrombosis
dc.subjectAnimal
dc.subjectArteriovenous Shunt, Surgical
dc.subjectAspirin
dc.subjectComparative Study
dc.subjectDipyridamole
dc.subjectDrug Therapy, Combination
dc.subjectHematocrit
dc.subjectHeparin
dc.subjectMale
dc.subjectPartial Thromboplastin Time
dc.subjectRabbits
dc.subjectRandom Allocation
dc.subjectRecurrence
dc.subjectThrombin Time
dc.subjectThrombophlebitis
dc.titleHeparin, heparin plus ASA and dipyridamole, and arteriovenous fistula as adjuvant methods to prevent rethrombosis after venous thrombectomy. Experimental study in rabbitsen
dc.typeArtigo
unesp.author.lattes8240785779318526
unesp.author.lattes3613835231654932
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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