Characterization of Atrazine-Loaded Biodegradable Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Microspheres

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dc.contributor.authorGrillo, Renato [UNESP]
dc.contributor.authorMelo, Nathalie F. S. de [UNESP]
dc.contributor.authorLima, Renata de
dc.contributor.authorLourenço, Roberto Wagner [UNESP]
dc.contributor.authorRosa, Andre Henrique [UNESP]
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de Sorocaba (UNISO)
dc.date.accessioned2014-05-20T13:12:11Z
dc.date.available2014-05-20T13:12:11Z
dc.date.issued2010-03-01
dc.description.abstractPolyhydroxybutyrate-co-hydroxyvalerate microspheres (PHBV-MS) were prepared as a delivery system for the herbicide atrazine (ATZ). Characterization of the system included investigation of in vitro release properties and genotoxicity. ATZ - PHBV-MS particle diameters showed a size distribution range of 1-13 mu m. Differential scanning calorimetry analyses indicated that ATZ was associated with the PHBV microparticles. The release profiles showed a different release behavior for the pure herbicide in solution, as compared with that containing ATZ-loaded PHBV-MS. Korsmeyer-Peppas model analyses showed that atrazine release from the microparticles occurred by a combination of diffusion through the matrix and partial diffusion through water-filled pores of the PHBV microparticles. A Lactuca sativa test result showed that the genotoxicity of ATZ-loaded PHBV-MP was decreased in relation to ATZ alone. The results demonstrate a viable biodegradable herbicide release system using atrazine for agrochemical purposes.en
dc.description.affiliationUnesp Univ Estadual Paulista, Dept Engn Ambiental, BR-18087180 Sorocaba, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Bioquim, Campinas, SP, Brazil
dc.description.affiliationUniv Sorocaba, Dept Biotecnol, Sorocaba, SP, Brazil
dc.description.affiliationUnespUnesp Univ Estadual Paulista, Dept Engn Ambiental, BR-18087180 Sorocaba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 08/01222-9
dc.description.sponsorshipIdFAPESP: 06/00121-0
dc.format.extent26-32
dc.identifierhttp://dx.doi.org/10.1007/s10924-009-0153-8
dc.identifier.citationJournal of Polymers and The Environment. New York: Springer/plenum Publishers, v. 18, n. 1, p. 26-32, 2010.
dc.identifier.doi10.1007/s10924-009-0153-8
dc.identifier.issn1566-2543
dc.identifier.lattes2188736885721242
dc.identifier.orcid0000-0002-2042-018X
dc.identifier.orcid0000-0002-0284-5782
dc.identifier.urihttp://hdl.handle.net/11449/170
dc.identifier.wosWOS:000278836800003
dc.language.isoeng
dc.publisherSpringer/plenum Publishers
dc.relation.ispartofJournal of Polymers and the Environment
dc.relation.ispartofjcr1.971
dc.relation.ispartofsjr0,562
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAtrazineen
dc.subjectPesticideen
dc.subjectPHBVen
dc.subjectMicrospheresen
dc.subjectRelease systemen
dc.titleCharacterization of Atrazine-Loaded Biodegradable Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Microspheresen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer/plenum Publishers
unesp.author.lattes5228846314663888[5]
unesp.author.lattes2188736885721242[1]
unesp.author.orcid0000-0002-2042-018X[5]
unesp.author.orcid0000-0002-0284-5782[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Sorocabapt

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