Phytoremediation Potential of Mana-Cubiu (Solanum sessiliflorum Dunal) for the Deleterious Effects of Methylmercury on the Reproductive System of Rats

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dc.contributor.authorSilva, Raquel Frenedoso da [UNESP]
dc.contributor.authorMissassi, Gabriela [UNESP]
dc.contributor.authorBorges, Cibele dos Santos [UNESP]
dc.contributor.authorPaula, Eloisa Silva de
dc.contributor.authorHornos Carneiro, Maria Fernanda
dc.contributor.authorGrotto, Denise
dc.contributor.authorBarbosa Junior, Fernando
dc.contributor.authorKempinas, Andwilma De Grava [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-12-03T13:10:56Z
dc.date.available2014-12-03T13:10:56Z
dc.date.issued2014-01-01
dc.description.abstractMethylmercury, organic form of mercury, can increase the number of abnormal sperm and decrease sperm concentration and testosterone levels possibly due to the damage caused by reactive species to germ and Leydig cells. Mana-cubiu (Solanum sessiliflorum Dunal) is a native fruit from Amazon rich in iron, zinc, niacin, pectin, and citric acid, used in foods, beverages, and medicinal purposes, since it has been useful for treatment of various diseases caused by oxidative stress or nutritional deficiency. Therefore, this study evaluated the phytoremediation potential of this fruit on damages caused by exposure to MeHg on sperm quantity and quality and the histological aspect of the testis and epididymis. Wistar male rats (n = 20) were randomly allocated into four groups: Control group (received distilled water), MeHg group (140 mu g/Kg), Solanum group (1% of fruit Mana-cubiu on chow), and Solanum plus MeHg group (same treatment as MeHg and Solanum group). The organs were weighted, histopathology; sperm morphology and counts were obtained. The results showed reduction in body weight gain, testis weights, reduced sperm production, and increased histopathological abnormalities in the MeHg-treated group. However, treatment with Solanum plus MeHg revealed a protective effect of this fruit on damages caused by MeHg.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Morphol, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Clin Anal Toxicol & Food Sci, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Morphol, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 13/05560-4
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1155/2014/309631
dc.identifier.citationBiomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.
dc.identifier.doi10.1155/2014/309631
dc.identifier.fileWOS000333627500001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/11449/112653
dc.identifier.wosWOS:000333627500001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBioMed Research International
dc.relation.ispartofjcr2.583
dc.relation.ispartofsjr0,935
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titlePhytoremediation Potential of Mana-Cubiu (Solanum sessiliflorum Dunal) for the Deleterious Effects of Methylmercury on the Reproductive System of Ratsen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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