Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR

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dc.contributor.authorSato, Monica Akemi
dc.contributor.authorSchoorlemmer, Gerhardus Hermanus Maria
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorLopes, Oswaldo Ubríaco
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFaculdade de Medicina do ABC (FMABC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:38Z
dc.date.available2014-05-20T13:45:38Z
dc.date.issued2003-10-01
dc.description.abstractAcute electrolytic lesions of the commissural nucleus of the solitary tract (commNTS) reduce blood pressure (BP) in SHR but not in normotensive Wistar-Kyoto and Wistar rats and abolish the pressor response to intravenous injection of potassium cyanide. We investigated the chronic effect of commNTS lesions on mean arterial pressure (MAP), and on baroreceptor and chemoreceptor reflex responses in SHR. The contribution of the sympathetic nervous system and the hormones vasopressin and angiotensin II to maintenance of BP in lesioned SHR was also investigated. MAP fell to normotensive levels the day after lesioning the commNTS but returned to the hypertensive level 9 days later. The reflex tachycardia evoked by sodium nitroprusside remained attenuated for 10 days after commNTS lesions but became enhanced 30 days after commNTS lesions. The pressor component of the chemoreflex elicited by potassium cyanide remained blocked for 30 days after lesions. Vasopressin antagonist or ACE blocker did not change MAP in sham or commNTS-lesioned SHR. Ganglionic blockade with hexamethonium elicited similar reductions in MAP in sham and commNTS-lesioned SHR. Results demonstrated that commNTS lesions in SHR produce a transient fall in BP and a long-lasting inhibition of the pressor response of the chemoreflex. Therefore, the blockade of the pressor response to peripheral chemoreflex activation is not sufficient to chronically reduce MAP in SHR. In the chronic absence of the commNTS, other subnuclei of the NTS or other brain stem nuclei may reorganize to replace the function of commNTS neurons, restoring sympathetic activity and high BP in SHR.en
dc.description.affiliationUniv Fed São Paulo, Escola Paulista Med, Dept Physiol, São Paulo, Brazil
dc.description.affiliationABC, Fac Med, Dept Physiol, Santo Andre, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Odontol, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.affiliationUnespDepartment of Physiology and Pathology, Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent713-718
dc.identifierhttp://dx.doi.org/10.1161/01.HYP.0000086523.51029.EC
dc.identifier.citationHypertension. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 4, p. 713-718, 2003.
dc.identifier.doi10.1161/01.HYP.0000086523.51029.EC
dc.identifier.fileWOS000185829100011.pdf
dc.identifier.issn0194-911X
dc.identifier.lattes1023597870118105
dc.identifier.lattes4544450092427426
dc.identifier.urihttp://hdl.handle.net/11449/16060
dc.identifier.wosWOS:000185829100011
dc.identifier.wosWOS:000185679000174
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofHypertension
dc.relation.ispartofjcr6.823
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbaroreceptorspt
dc.subjectchemoreceptorspt
dc.subjectblood pressurept
dc.subjectrats, spontaneously hypertensivept
dc.titleRecovery of high blood pressure after chronic lesions of the commissural NTS in SHRen
dc.typeArtigo
dcterms.licensehttp://atvb.ahajournals.org/site/misc/ifora.xhtml
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.lattes1023597870118105
unesp.author.lattes4544450092427426[5]
unesp.author.orcid0000-0002-1395-4036[5]
unesp.author.orcid0000-0003-1167-4441[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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