Propolis effect on streptozotocin-induced diabetic rats

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dc.contributor.authorSartori, D. R.S. [UNESP]
dc.contributor.authorKawakami, C. L. [UNESP]
dc.contributor.authorOrsatti, C. L. [UNESP]
dc.contributor.authorSforcin, José Maurício [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:51:53Z
dc.date.available2022-04-28T20:51:53Z
dc.date.issued2009-05-28
dc.description.abstractPropolis is one of the hive products that has been used extensively in folk medicine, due to its several biological and pharmacological properties. Besides, propolis-containing products have been intensely marketed by the pharmaceutical industry and health-food stores. This work was carried out in order to investigate whether propolis treatment could revert the metabolic alterations of streptozotocin-induced diabetic rats. Animals were kept in metabolic cages and diabetes was induced by a single dose of streptozotocin (35 mg/kg, IV). After a week, rats with glycemia higher than 230 mg/dL were divided into two groups and treated with ethanolic extract of propolis (10 and 90 mg/kg, PO) for seven days. Glycemia and free fatty acids were determined, as well as food and water intake, body weight and urine volume were registered weekly. Data showed no significant differences in the analyzed variables. Based on these results, one may conclude that propolis had no effects after diabetes establishment, in our conditions assays. Further assays with different concentrations of propolis and periods of administration should be carried out in order to evaluate its therapeutic potential in this disease.en
dc.description.affiliationDepartment of Physiology Botucatu Biosciences Institute São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartment of Microbiology and Immunology Botucatu Biosciences Institute São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartamento de Microbiologia e Imunologia Instituto de Biociências UNESP, Botucatu, SP, 18618-000
dc.description.affiliationUnespDepartment of Physiology Botucatu Biosciences Institute São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Microbiology and Immunology Botucatu Biosciences Institute São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartamento de Microbiologia e Imunologia Instituto de Biociências UNESP, Botucatu, SP, 18618-000
dc.format.extent93-102
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992009000100009
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 15, n. 1, p. 93-102, 2009.
dc.identifier.doi10.1590/S1678-91992009000100009
dc.identifier.issn1678-9199
dc.identifier.scopus2-s2.0-65749108270
dc.identifier.urihttp://hdl.handle.net/11449/225474
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.sourceScopus
dc.subjectBrazilian propolis
dc.subjectDiabetes
dc.subjectFree fatty acids
dc.subjectGlucose
dc.titlePropolis effect on streptozotocin-induced diabetic ratsen
dc.typeArtigo

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Artigos - Fisiologia - IBB
Artigos - Microbiologia e Imunologia - IBB