Diabetes increases interleukin-17 levels in periapical, hepatic, and renal tissues in rats

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dc.contributor.authorAzuma, Mariane Maffei [UNESP]
dc.contributor.authorGomes-Filho, João Eduardo [UNESP]
dc.contributor.authorPrieto, Annelise Katrine Carrara [UNESP]
dc.contributor.authorSamuel, Renata Oliveira [UNESP]
dc.contributor.authorde Lima, Valéria Marçal Felix [UNESP]
dc.contributor.authorSumida, Dóris Hissako [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIngá University Center
dc.contributor.institutionUniversity of Uberaba
dc.date.accessioned2018-12-11T17:14:45Z
dc.date.available2018-12-11T17:14:45Z
dc.date.issued2017-11-01
dc.description.abstractObjectives This study aimed to evaluate the association between endodontic infection and diabetes on interleukin-17 levels in periapical, hepatic, and renal tissues of rats. Design Forty male rats were divided into groups: normoglycemic rats (N), normoglycemic rats with apical periodontitis (N-AP), rats with experimental diabetes (ED), and rats with experimental diabetes and apical periodontitis (ED-AP). Diabetes was induced by intravenous streptozotocin injection, and blood sugar levels were monitored to confirm disease development. Apical periodontitis (AP) was induced by pulp exposure to the oral environment during 30 days. After 30 days, hepatic and renal tissues were obtained, and IL-17 levels were quantified by ELISA. The right hemi-jaw was used to quantify IL-17 levels by immunohistochemistry. The values obtained in parametric tests were tabulated and analyzed statistically by analysis of variance (ANOVA) and Tukey tests, and the values obtained for scores were statistically analyzed by using the Kruskal-Wallis and Dun tests. The level of significance was set at 5%. Results ED and ED-AP groups expressed significantly higher IL-17 levels in both hepatic and renal tissues (p < 0.05), compared to N and N-AP groups. Apical periodontitis (AP) in ED-AP group was significantly more severe than that in N-AP group (p < 0.05). Furthermore, there was a significantly larger increase in the IL-17 levels in ED-AP group compared to N group (p < 0.05). Conclusion Our results indicate that diabetes increases IL-17 levels in hepatic and renal tissues and also enhances IL-17 production in apical periodontitis area of rats.en
dc.description.affiliationDepartment of Endodontics São Paulo State University (Unesp) School of Dentistry, Araçatuba, Rua José Bonifácio, 1193
dc.description.affiliationDepartment of Clinic and Surgery and Animal Reproduction São Paulo State University (Unesp) Araçatuba Veterinary Medicine, Rua Clóvis Pestana, 793
dc.description.affiliationDepartment of Basic Science São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationDepartment of Endodontics Ingá University Center, UNINGÁ, Rod. PR 317, 6114- Parque Industrial 200, Maringá
dc.description.affiliationDepartment of Clinical Dentistry Dental School UNIUBE University of Uberaba, Av. Nenê Sabino, 1801, Uberaba, 38055-500, Minas Gerais
dc.description.affiliationUnespDepartment of Endodontics São Paulo State University (Unesp) School of Dentistry, Araçatuba, Rua José Bonifácio, 1193
dc.description.affiliationUnespDepartment of Clinic and Surgery and Animal Reproduction São Paulo State University (Unesp) Araçatuba Veterinary Medicine, Rua Clóvis Pestana, 793
dc.description.affiliationUnespDepartment of Basic Science São Paulo State University (Unesp) School of Dentistry
dc.format.extent230-235
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2017.08.001
dc.identifier.citationArchives of Oral Biology, v. 83, p. 230-235.
dc.identifier.doi10.1016/j.archoralbio.2017.08.001
dc.identifier.file2-s2.0-85029672233.pdf
dc.identifier.issn1879-1506
dc.identifier.issn0003-9969
dc.identifier.lattes4408095517346846
dc.identifier.lattes9235743081667362
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85029672233
dc.identifier.urihttp://hdl.handle.net/11449/175189
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectApical periodontitis
dc.subjectDiabetes
dc.subjectEndodontic infection
dc.subjectInterleukin-17
dc.titleDiabetes increases interleukin-17 levels in periapical, hepatic, and renal tissues in ratsen
dc.typeArtigo
unesp.author.lattes4408095517346846[7]
unesp.author.lattes9235743081667362
unesp.author.orcid0000-0003-4859-0583[7]

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Artigos - Odontologia Restauradora - FOA
Artigos - Clínica, Cirurgia e Reprodução Animal - FMVA