Frequency and burden of neurological manifestations upon hospital presentation in COVID-19 patients: Findings from a large Brazilian cohort

dc.contributor.authorMarcolino, Milena Soriano
dc.contributor.authorAnschau, Fernando
dc.contributor.authorKopittke, Luciane
dc.contributor.authorPires, Magda Carvalho
dc.contributor.authorBarbosa, Izabela Guimarães
dc.contributor.authorPereira, Daniella Nunes
dc.contributor.authorRamos, Lucas Emanuel Ferreira
dc.contributor.authorAssunção, Luís Fernando Israel
dc.contributor.authorCosta, André Soares de Moura
dc.contributor.authorNogueira, Matheus Carvalho Alves
dc.contributor.authorDuani, Helena
dc.contributor.authorMartins, Karina Paula Medeiros Prado
dc.contributor.authorMoreira, Leila Beltrami
dc.contributor.authorSilva, Carla Thais Cândida Alves da
dc.contributor.authorOliveira, Neimy Ramos de
dc.contributor.authorZiegelmann, Patricia Klarmann
dc.contributor.authorGuimarães-Júnior, Milton Henriques
dc.contributor.authorLima, Mauro Oscar Soares de Souza
dc.contributor.authorAguiar, Rubia Laura Oliveira
dc.contributor.authorMenezes, Luanna Silva Monteiro
dc.contributor.authorOliveira, Talita Fischer
dc.contributor.authorSouza, Maíra Dias
dc.contributor.authorFarace, Bárbara Lopes
dc.contributor.authorCimini, Christiane Corrêa Rodrigues
dc.contributor.authorMaurílio, Amanda de Oliveira
dc.contributor.authorGuimarães, Silvana Mangeon Mereilles
dc.contributor.authorAraújo, Silvia Ferreira
dc.contributor.authorNascimento, Guilherme Fagundes
dc.contributor.authorSilveira, Daniel Vitório
dc.contributor.authorRuschel, Karen Brasil
dc.contributor.authorOliveira, Thainara Conceição de
dc.contributor.authorSchwarzbold, Alexandre Vargas
dc.contributor.authorNasi, Luiz Antônio
dc.contributor.authorFloriani, Maiara Anschau
dc.contributor.authorSantos, Veridiana Baldon dos
dc.contributor.authorRamos, Carolina Marques
dc.contributor.authorAlvarenga, Joice Coutinho de
dc.contributor.authorScotton, Ana Luiza Bahia Alves
dc.contributor.authorManenti, Euler Roberto Fernandes
dc.contributor.authorCrestani, Gabriela Petry
dc.contributor.authorBatista, Joanna d'Arc Lyra
dc.contributor.authorPonce, Daniela [UNESP]
dc.contributor.authorMachado-Rugolo, Juliana [UNESP]
dc.contributor.authorBezerra, Adriana Falangola Benjamin
dc.contributor.authorMartelli, Petrônio José de Lima
dc.contributor.authorVianna, Heloisa Reniers
dc.contributor.authorCastro, Luís César de
dc.contributor.authorMedeiros, Cássia Regina Gotler
dc.contributor.authorVietta, Giovanna Grunewald
dc.contributor.authorPereira, Elayne Crestani
dc.contributor.authorChatkin, José Miguel
dc.contributor.authorGodoy, Mariana Frizzo de
dc.contributor.authorDelfino-Pereira, Polianna
dc.contributor.authorTeixeira, Antonio Lucio
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionInstitute for Health Technology Assessment (IATS/ CNPq)
dc.contributor.institutionHospital Nossa Senhora da Conceição and Hospital Cristo Redentor.
dc.contributor.institutionHospitais da Rede Mater Dei.
dc.contributor.institutionHospital de Clínicas de Porto Alegre
dc.contributor.institutionHospital Santo Antônio
dc.contributor.institutionHospital Eduardo de Menezes
dc.contributor.institutionHospital Tacchini.
dc.contributor.institutionHospital Márcio Cunha
dc.contributor.institutionHospital Metropolitano Doutor Célio de Castro
dc.contributor.institutionHospital Luxemburgo.
dc.contributor.institutionHospital Metropolitano Odilon Behrens
dc.contributor.institutionHospital Risoleta Tolentino Neves
dc.contributor.institutionHospital Santa Rosália.
dc.contributor.institutionHospital São João de Deus
dc.contributor.institutionHospital Semper
dc.contributor.institutionHospital Unimed BH
dc.contributor.institutionHospital Universitário Canoas
dc.contributor.institutionHospital Universitário de Santa Maria
dc.contributor.institutionHospital Moinhos de Vento
dc.contributor.institutionHospital Julia Kubitschek
dc.contributor.institutionHospital João XXIII
dc.contributor.institutionHospital Regional Antônio Dias
dc.contributor.institutionHospital Mãe de Deus
dc.contributor.institutionUniversidade Federal Fronteira do Sul.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionHospital Universitário Ciências Médicas
dc.contributor.institutionHospital Bruno Born
dc.contributor.institutionHospital SOS Cárdio
dc.contributor.institutionHospital São Lucas PUCRS
dc.contributor.institutionFaculdade Santa Casa BH
dc.contributor.institutionUT Health Houston
dc.date.accessioned2023-07-29T13:27:56Z
dc.date.available2023-07-29T13:27:56Z
dc.date.issued2022-12-15
dc.description.abstractBackground: Scientific data regarding the prevalence of COVID-19 neurological manifestations and prognosis in Latin America countries is still lacking. Therefore, the study aims to understand neurological manifestations of SARS-CoV 2 infection and outcomes in the Brazilian population. Methods: This study is part of the Brazilian COVID-19 Registry, a multicentric cohort, including data from 37 hospitals. For the present analysis, patients were grouped according to the presence of reported symptoms (i.e., headache; anosmia and ageusia; syncope and dizziness) vs. clinically-diagnosed neurological manifestations (clinically-defined neurological syndrome: neurological signs or diagnoses captured by clinical evaluation) and matched with patients without neurological manifestations by age, sex, number of comorbidities, hospital of admission, and whether or not patients had underlying neurological disease. Results: From 6,635 hospitalized patients with COVID-19, 30.8% presented reported neurological manifestations, 10.3% were diagnosed with a neurological syndrome and 60.1% did not show any neurological manifestations. In patients with reported symptoms, the most common ones were headache (20.7%), ageusia (11.1%) and anosmia (8.0%). In patients with neurological syndromes, acute encephalopathy was the most common diagnosis (9.7%). In the matched analysis, patients with neurological syndromes presented more cases of septic shock (17.0 vs. 13.0%, p = 0.045), intensive care unit admission (45.3 vs. 38.9%, p = 0.023), and mortality (38.7 vs. 32.6%, p = 0.026; and 39.2 vs. 30.3%, p < 0.001) when compared to controls. Conclusion: COVID-19 in-hospital patients with clinically defined neurological syndromes presented a higher incidence of septic shock, ICU admission and death when compared to controls.en
dc.description.affiliationDepartment of Internal Medicine Medical School Universidade Federal de Minas Gerais., Av. Professor Alfredo Balena 110Belo Horizonte
dc.description.affiliationTelehealth Center University Hospital Universidade Federal de Minas Gerais., Av. Professor Alfredo Balena 190, sala 246
dc.description.affiliationInstitute for Health Technology Assessment (IATS/ CNPq), R. Ramiro Barcelos, 2359, Prédio 21, Sala 507
dc.description.affiliationGrupo Hospitalar Conceição Brazilian National Health System Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor., Av. Francisco Trein, 326
dc.description.affiliationDepartment of Statistics Universidade Federal de Minas Gerais., Av. Presidente Antônio Carlos, 6627, ICEx, sala 4071
dc.description.affiliationMental Health Department Medical School Universidade Federal de Minas Gerais., Av. Professor Alfredo Balena 190sala 246
dc.description.affiliationMedical School Universidade Federal de Minas Gerais., Av. Professor Alfredo Balena190
dc.description.affiliationHospitais da Rede Mater Dei., Av. do Contorno, 9000
dc.description.affiliationHospital de Clínicas de Porto Alegre, Av. Protásio Alves, 211
dc.description.affiliationHospital Santo Antônio, Pç. Dr. Márcio Carvalho Lopes Filho, 501
dc.description.affiliationHospital Eduardo de Menezes, R. Dr. Cristiano Rezende, 2213
dc.description.affiliationHospital Tacchini., R. Dr. José Mário Mônaco, 358
dc.description.affiliationHospital Márcio Cunha, Av. Kiyoshi Tsunawaki, 41
dc.description.affiliationHospital Metropolitano Doutor Célio de Castro, R. Dona Luiza, 311
dc.description.affiliationInstituto Mário Penna Hospital Luxemburgo., R. Joaquim Cândido Filho, 91
dc.description.affiliationHospital Metropolitano Odilon Behrens, . R. Formiga, 50
dc.description.affiliationHospital Risoleta Tolentino Neves, R. das Gabirobas, 01
dc.description.affiliationHospital Santa Rosália., R. Dr. Onófre, 575
dc.description.affiliationHospital São João de Deus, R. do Cobre, 800
dc.description.affiliationHospital Semper, . Alameda Ezequiel Dias, 389
dc.description.affiliationHospital Unimed BH, Av. do Contorno, 3097
dc.description.affiliationHospital Universitário Canoas, Av. Farroupilha, 8001, Rio Grande do Sul
dc.description.affiliationHospital Universitário de Santa Maria, Av. Roraima, 1000, Rio Grande do Sul
dc.description.affiliationHospital Moinhos de Vento, R. Ramiro Barcelos, 910, Rio Grande do Sul
dc.description.affiliationHospital Julia Kubitschek, Av. Professor Alfredo Balena, 190
dc.description.affiliationHospital João XXIII, Av. Professor Alfredo Balena, 400
dc.description.affiliationHospital Regional Antônio Dias, R. Maj. Gote, 1231
dc.description.affiliationHospital Mãe de Deus, R. José de Alencar, 286
dc.description.affiliationUniversidade Federal Fronteira do Sul., Av. Fernando Machado, 108E
dc.description.affiliationHospital das Clínicas da Faculdade de Medicina de Botucatu, Av. Professor Mário Rubens Guimarães Montenegro, São Paulo
dc.description.affiliationHospital das Clínicas da Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235
dc.description.affiliationHospital Universitário Ciências Médicas, R. dos Aimorés, 2896
dc.description.affiliationHospital Bruno Born, Av. Benjamin Constant, 881
dc.description.affiliationHospital SOS Cárdio, Rod. SC-401, 121
dc.description.affiliationHospital São Lucas PUCRS, Av. Ipiranga, 6690
dc.description.affiliationFaculdade Santa Casa BH, Av. dos Andradas, 2688
dc.description.affiliationNeuropsychiatry Program Department of Psychiatry and Behavioral Sciences UT Health Houston, 7000 Fannin St
dc.description.affiliationUnespHospital das Clínicas da Faculdade de Medicina de Botucatu, Av. Professor Mário Rubens Guimarães Montenegro, São Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.identifierhttp://dx.doi.org/10.1016/j.jns.2022.120485
dc.identifier.citationJournal of the Neurological Sciences, v. 443.
dc.identifier.doi10.1016/j.jns.2022.120485
dc.identifier.issn1878-5883
dc.identifier.issn0022-510X
dc.identifier.scopus2-s2.0-85141757629
dc.identifier.urihttp://hdl.handle.net/11449/247863
dc.language.isoeng
dc.relation.ispartofJournal of the Neurological Sciences
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectDelirium
dc.subjectNeurologic manifestations
dc.subjectPrognosis
dc.titleFrequency and burden of neurological manifestations upon hospital presentation in COVID-19 patients: Findings from a large Brazilian cohorten
dc.typeArtigo

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