Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

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dc.contributor.authorCalvo, Tamara Regina [UNESP]
dc.contributor.authorPrimila Cardoso, Cassia Regina [UNESP]
dc.contributor.authorda Silva Moura, Adriana Candido [UNESP]
dc.contributor.authorSantos, Lourdes Campaner dos [UNESP]
dc.contributor.authorSyllos Colus, Ilce Mara
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-20T13:24:18Z
dc.date.available2014-05-20T13:24:18Z
dc.date.issued2011-01-01
dc.description.abstractIndigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.en
dc.description.affiliationUNESP São Paulo State Univ, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Inst Quim Araraquara, Dept Quim Organ, BR-14800900 São Paulo, Brazil
dc.description.affiliationUEL Londrina State Univ, Ctr Biol Sci, Dept Gen Biol, BR-86051990 Londrina, PR, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Inst Quim Araraquara, Dept Quim Organ, BR-14800900 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1093/ecam/nep123
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 9, 2011.
dc.identifier.doi10.1093/ecam/nep123
dc.identifier.fileWOS000293413300001.pdf
dc.identifier.issn1741-427X
dc.identifier.lattes3538253640602977
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7500
dc.identifier.wosWOS:000293413300001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleMutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Partsen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes3538253640602977
unesp.author.orcid0000-0003-3032-2556[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Ciências Biológicas - FCFAR
Artigos - Química Orgânica - IQ