Organophosphorus-induced delayed neuropathy: A simple and efficient therapeutic strategy

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dc.contributor.authorEmerick, Guilherme Luz [UNESP]
dc.contributor.authorPeccinini, Rosangela Goncalves [UNESP]
dc.contributor.authorde Oliveira, Georgino H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:33Z
dc.date.available2014-05-20T13:25:33Z
dc.date.issued2010-02-01
dc.description.abstractOrganophosphorus (OP) used as pesticides and hydraulic fluids can produce acute poisoning known as OP-induced delayed neuropathy (OPIDN), whose effects take long time to recover. Thus a secure therapeutic strategy to prevent the most serious effects of this poisoning would be welcome. In this study, tri-o-cresyl phosphate (TOCP, 500 mg/kg p.o.) was given to hens, followed or not by nimodipine (1 mg/kg i.m.) and calcium gluconate (Ca-glu 5 mg/kg i.v.). Six hours after TOCP intoxication, neuropathy target esterase (NTE) activity inhibition was observed, peaking after 24 It exceeding 80% inhibition. A fall in the plasmatic calcium levels was noted 12 h after TOCP was given and, in the sciatic nerve, Ca(2+) fell 56.4% 24 h later; at the same time calcium activated neutral protease (CANP) activity increased 308.7%, an effect that lasted 14 days. Any bird that received therapeutic treatment after TOCP intoxication presented significant signs of OPIDN. These results suggest that NTE may be implicated in the regulation of calcium entrance into cells being responsible for the maintenance of normal function of calcium channels, and that increasing CANP activity is responsible to triggering OPIDN. Thus, with one suitably adjusted dose of nimodipine as well as Ca-glu, we believe that this treatment strategy may be used in humans with acute poisoning by neuropathic OP. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP São Paulo State Univ, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, BR-14801902 São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Sch Pharmaceut Sci, Pharmaceut Sci Graduat Program, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Pharmaceut Sci, Pharmaceut Sci Graduat Program, BR-14801902 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipSchool of Pharmaceutical Science UNESP Araraquara, São Paulo State University, Brazil
dc.description.sponsorshipIdFAPESP: 8/58761-9
dc.format.extent238-244
dc.identifierhttp://dx.doi.org/10.1016/j.toxlet.2009.10.032
dc.identifier.citationToxicology Letters. Clare: Elsevier B.V., v. 192, n. 2, p. 238-244, 2010.
dc.identifier.doi10.1016/j.toxlet.2009.10.032
dc.identifier.issn0378-4274
dc.identifier.lattes1066743423929093
dc.identifier.urihttp://hdl.handle.net/11449/8108
dc.identifier.wosWOS:000274743300022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicology Letters
dc.relation.ispartofjcr3.166
dc.relation.ispartofsjr1,103
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectTOCPen
dc.subjectDelayed neuropathyen
dc.subjectCANPen
dc.subjectNimodipineen
dc.subjectCalcium gluconateen
dc.subjectTreatmenten
dc.titleOrganophosphorus-induced delayed neuropathy: A simple and efficient therapeutic strategyen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1066743423929093
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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