Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women

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dc.contributor.authorZaros, Pedro R. [UNESP]
dc.contributor.authorPires, Carla E.M. Romero [UNESP]
dc.contributor.authorBacci Jr., Mauricio [UNESP]
dc.contributor.authorMoraes, Camila
dc.contributor.authorZanesco, Angelina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCruzeiro do Sul University
dc.date.accessioned2014-05-27T11:23:55Z
dc.date.available2014-05-27T11:23:55Z
dc.date.issued2009-06-19
dc.description.abstractBackground: Evidences have showed that the incidence of arterial hypertension is greater in postmenopausal women as compared to premenopausal. Physical inactivity has been implicated as a major contributor to weight gain and abdominal obesity in postmenopausal women and the incidence of cardiovascular disease increases dramatically after menopause. Additionally, more women than men die each year of coronary heart disease and are twice as likely as men to die within the first year after a heart attack. A healthy lifestyle has been strongly associated with the regular physical activity and evidences have shown that physically active subjects have more longevity with reduction of morbidity and mortality. Nitric oxide (NO) produced by endothelial cells has been implicated in this beneficial effect with improvement of vascular relaxing and reduction in blood pressure in both laboratory animals and human. Although the effect of exercise training in the human cardiovascular system has been largely studied, the majority of these studies were predominantly conducted in men or young volunteers. Therefore, the aim of this work was to investigate the effects of 6 months of dynamic exercise training (ET) on blood pressure and plasma nitrate/nitrite concentration (NOx-) in hypertensive postmenopausal women. Methods: Eleven volunteers were submitted to the ET consisting in 3 days a week, each session of 60 minutes during 6 months at moderate intensity (50% of heart rate reserve). Anthropometric parameters, blood pressure, NOx- concentration were measured at initial time and after ET. Results: A significant reduction in both systolic and diastolic blood pressure values was seen after ET which was accompanied by markedly increase of NOx- levels (basal: 10 ± 0.9; ET: 16 ± 2 μM). Total cholesterol was significantly reduced (basal: 220 ± 38 and ET: 178 ± 22 mg/dl), whereas triglycerides levels were not modified after ET (basal: 141 ± 89 and ET: 147 ± 8 mg/dl). Conclusion: Our study shows that changing in lifestyle promotes reducftion of arterial pressure which was accompanied by increase in nitrite/nitrate concentration. Therefore, 6-months of exercise training are an important approach in management arterial hypertension and play a protective effect in postmenopausal women. © 2009 Zaros et al; licensee BioMed Central Ltd.en
dc.description.affiliationDepartment of Physical Education Institute of Biosciences University of Sao Paulo State (UNESP), Rio Claro, SP
dc.description.affiliationDepartmento of Biochemistry University of Sao Paulo State (UNESP), Rio Claro, SP
dc.description.affiliationInstitute of Physical Activity and Sports Cruzeiro do Sul University, Sao Paulo, SP
dc.description.affiliationUnespDepartment of Physical Education Institute of Biosciences University of Sao Paulo State (UNESP), Rio Claro, SP
dc.description.affiliationUnespDepartmento of Biochemistry University of Sao Paulo State (UNESP), Rio Claro, SP
dc.identifierhttp://dx.doi.org/10.1186/1472-6874-9-17
dc.identifier.citationBMC Women's Health, v. 9.
dc.identifier.doi10.1186/1472-6874-9-17
dc.identifier.file2-s2.0-68249156603.pdf
dc.identifier.issn1472-6874
dc.identifier.lattes4472007237545596
dc.identifier.scopus2-s2.0-68249156603
dc.identifier.urihttp://hdl.handle.net/11449/71040
dc.language.isoeng
dc.relation.ispartofBMC Women's Health
dc.relation.ispartofjcr1.806
dc.relation.ispartofsjr0,931
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectnitrate
dc.subjectnitric oxide
dc.subjecttriacylglycerol
dc.subjectcholesterol
dc.subjectnitrite
dc.subjectadult
dc.subjectanthropometry
dc.subjectblood pressure monitoring
dc.subjectbody mass
dc.subjectcholesterol blood level
dc.subjectclinical article
dc.subjectdiastolic blood pressure
dc.subjectdynamic exercise
dc.subjectenzyme blood level
dc.subjectfemale
dc.subjectglucose blood level
dc.subjectheart rate
dc.subjecthuman
dc.subjecthypertension
dc.subjectpostmenopause
dc.subjectsystolic blood pressure
dc.subjecttreatment duration
dc.subjecttreatment response
dc.subjecttriacylglycerol blood level
dc.subjectwaist hip ratio
dc.subjectblood
dc.subjectblood pressure
dc.subjectclinical trial
dc.subjectkinesiotherapy
dc.subjectmethodology
dc.subjectmiddle aged
dc.subjecttreatment outcome
dc.subjectBlood Pressure
dc.subjectBody Mass Index
dc.subjectCholesterol
dc.subjectExercise Therapy
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectHypertension
dc.subjectMiddle Aged
dc.subjectNitrates
dc.subjectNitrites
dc.subjectPostmenopause
dc.subjectTreatment Outcome
dc.titleEffect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal womenen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
unesp.author.lattes4472007237545596
unesp.author.orcid0000-0002-5619-1411[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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