Low-intensity laser therapy efficacy evaluation in FVB mice subjected to acute and chronic arthritis

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dc.contributor.authorMardegan Issa, Joao Paulo
dc.contributor.authorTrawitzki, Bianca Ferreira
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorMacedo, Ana Paula
dc.contributor.authorLilge, Lothar
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Hlth Network
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Toronto
dc.date.accessioned2018-11-28T16:42:20Z
dc.date.available2018-11-28T16:42:20Z
dc.date.issued2017-08-01
dc.description.abstractRheumatoid arthritis, an autoimmune inflammation, has a high prevalence in the population, and while therapy is available, it required often injection of drugs causing discomfort to patients. This study evaluates the clinical and histological effect of low-intensity laser therapy (LILT) as an alternative treatment, in a murine model of acute and chronic inflammation. FVB mice received either a Zymosan A injection into one knee joint inducing acute inflammation, followed after 15 min or 24 h by LILT or a collagen bovine type II injection emulsified in Freund's Complete Adjuvant to induce chronic arthritis, followed at 4 weeks with multiple LILT sessions. LILT mediated by either 660, 808, or 905 nm and tissue response was evaluated based on clinical symptoms and histological analysis of inflammatory infiltrate and damage to the articular surfaces. LILT can be effective in elevating clinical symptoms, so Kruskal-Wallis testing indicated no significant differences between knees affected by acute arthritis and treated once with LILT and an injured knee without treatment (p > 0.05) for 660 and 808 nm with some improvements for the 905-nm LILT. Mice receiving two treatments for acute arthritis showed exacerbation of inflammation and articular resorption following therapy with a 660-nm continuous laser (p < 0.05). For chronic inflammation, differences were not noted between LILT treated and untreated injured knee joints (p > 0.05). Among the lasers, the 905 nm tends to show better results for anti-inflammatory effect in acute arthritis, and the 660 nm showed better results in chronic arthritis. In conclusion, LILT wavelength selection depends on the arthritis condition and can demonstrate anti-inflammatory effects for chronic arthritis and reduced resorption area in this murine model.en
dc.description.affiliationUniv Sao Paulo, Sch Dent Ribeirao Preto, Sao Paulo, Brazil
dc.description.affiliationUniv Hlth Network, Princess Margaret Canc Ctr, 101 Coll St, Toronto, ON M5G 1L7, Canada
dc.description.affiliationUniv Estadual Paulista, Aracatuba, SP, Brazil
dc.description.affiliationUniv Toronto, Dept Med Biophys, Toronto, ON, Canada
dc.description.affiliationUnespUniv Estadual Paulista, Aracatuba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipOntario Ministry of Health and Long-Term Care
dc.description.sponsorshipPrincess Margaret Cancer Centre
dc.format.extent1269-1277
dc.identifierhttp://dx.doi.org/10.1007/s10103-017-2235-5
dc.identifier.citationLasers In Medical Science. London: Springer London Ltd, v. 32, n. 6, p. 1269-1277, 2017.
dc.identifier.doi10.1007/s10103-017-2235-5
dc.identifier.fileWOS000406601200006.pdf
dc.identifier.issn0268-8921
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.urihttp://hdl.handle.net/11449/165689
dc.identifier.wosWOS:000406601200006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLasers In Medical Science
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectInflammation
dc.subjectLilt
dc.subjectHistology
dc.subjectImmunohistochemistry
dc.subjectRepair
dc.titleLow-intensity laser therapy efficacy evaluation in FVB mice subjected to acute and chronic arthritisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes4408095517346846[3]
unesp.author.orcid0000-0003-4859-0583[3]

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