Intravenous Tramadol Injection has no Antinociceptive Effect in Horses Undergoing Electrical and Thermal Stimuli

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dc.contributor.authorSanti Milaré, Anelize
dc.contributor.authorde Oliveira, Flávia Augusta
dc.contributor.authorLuna, Stélio Pacca Loureiro [UNESP]
dc.contributor.authorRizzo Scognamillo, Márcia Valéria
dc.contributor.authorde Queiroz-Neto, Antonio
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:33Z
dc.date.available2014-05-27T11:28:33Z
dc.date.issued2013-02-28
dc.description.abstractTramadol combines an μ opiate and nonopiate analgesic mechanism and might be a useful opioid in horses. This study evaluated the effect of IV tramadol on spontaneous locomotor activity (SLA), head height, and hoof withdrawal reflex (HWR) after thermal or electrical nociceptive stimuli in horses. Doses of 2 and 3 mg/kg tramadol did not affect HWR after electrical and thermal nociception, respectively. Head height and SLA were not modified by 2, 3, or 5 mg/kg tramadol. All horses treated with 5 mg/kg tramadol developed trembling in pectoral triceps, and gluteal muscles and adopted a base-wide stance. In conclusion, 2 and 3 mg/kg tramadol IV neither induced sedation nor prolonged HWR after thermal or electrical stimuli in conscious horses. The dose of 5 mg/kg tramadol IV produced excitement, and it is apparently unsuitable for clinical use. © 2013 Elsevier Inc. All rights reserved.en
dc.identifierhttp://dx.doi.org/10.1016/j.jevs.2012.12.010
dc.identifier.citationJournal of Equine Veterinary Science.
dc.identifier.doi10.1016/j.jevs.2012.12.010
dc.identifier.issn0737-0806
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.scopus2-s2.0-84874199538
dc.identifier.urihttp://hdl.handle.net/11449/74635
dc.identifier.wosWOS:000326254100010
dc.language.isoeng
dc.relation.ispartofJournal of Equine Veterinary Science
dc.relation.ispartofjcr0.880
dc.relation.ispartofsjr0,390
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAntinociception
dc.subjectHorses
dc.subjectOpioid
dc.subjectSpontaneous locomotor activity
dc.titleIntravenous Tramadol Injection has no Antinociceptive Effect in Horses Undergoing Electrical and Thermal Stimulien
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[3]
unesp.author.orcid0000-0002-3643-8958[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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