Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats

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dc.contributor.authorda Silva Moreira, Suyane [UNESP]
dc.contributor.authorde Lima Inocêncio, Leonardo Cesar [UNESP]
dc.contributor.authorJorge, Bárbara Campos [UNESP]
dc.contributor.authorReis, Ana Carolina Casali [UNESP]
dc.contributor.authorHisano, Hamilton
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.date.accessioned2021-06-25T10:47:23Z
dc.date.available2021-06-25T10:47:23Z
dc.date.issued2021-05-01
dc.description.abstractStudies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of BaP (0; 0.1; 1.0 or 10 μg/kg) to pregnant Wistar rats from Gestational day (GD) 6 to GD 15 (the organogenesis period). Pregnant rats did not exhibit clinical signs of toxicity during the exposure period. However, dams exposed to the lowest dose of BaP showed a reduction in the erythrocytes number and in the creatinine levels. The groups exposed to 0.1 and 1.0 μg/kg presented a decrease in placental efficiency, as well as an increase in placental weight. After fetal examination, the treated group with the lowest dose showed a reduced relative anogenital distance, while the curve of normal distribution of weight was changed in the highest dose group. In addition, anomalies evidenced by changes in the renal size and degree of fetal ossification were observed in treated-fetus. In conclusion, treatment with BaP during organogenesis at this dose level is detrimental to the normal development of fetuses.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)
dc.description.affiliationEmbrapa Environment
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista–Botucatu (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: #2018/07394-8
dc.description.sponsorshipIdFAPESP: #2018/07967-8
dc.format.extent831-839
dc.identifierhttp://dx.doi.org/10.1002/tox.23085
dc.identifier.citationEnvironmental Toxicology, v. 36, n. 5, p. 831-839, 2021.
dc.identifier.doi10.1002/tox.23085
dc.identifier.issn1522-7278
dc.identifier.issn1520-4081
dc.identifier.scopus2-s2.0-85097864216
dc.identifier.urihttp://hdl.handle.net/11449/206999
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology
dc.sourceScopus
dc.subjectorganogenesis
dc.subjectpolycyclic aromatic hydrocarbon
dc.subjectrats
dc.subjectskeletal abnormalities
dc.subjectteratogenicity
dc.titleEffects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-0445-2755[5]
unesp.author.orcid0000-0002-2373-9399[6]

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Botucatu - CEATOX - Centro de Assistência Toxicológica