Acetone as a greener alternative to acetonitrile in liquid chromatographic fingerprinting

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dc.contributor.authorFunari, Cristiano Soleo [UNESP]
dc.contributor.authorCarneiro, Renato Lajarim
dc.contributor.authorKhandagale, Manish M.
dc.contributor.authorCavalheiro, Alberto Jose [UNESP]
dc.contributor.authorHilder, Emily F.
dc.contributor.institutionUniversity of Tasmania
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2015-10-22T06:19:20Z
dc.date.available2015-10-22T06:19:20Z
dc.date.issued2015-05-01
dc.description.abstractA considerable amount of chemical waste from liquid chromatography analysis is generated worldwide. Acetonitrile is the most employed solvent in liquid chromatography analyses since it exhibits favorable physicochemical properties for separation and detection, but it is an unwelcome solvent from an environmental point of view. Acetone might be a much greener alternative to replace acetonitrile in reversed-phase liquid chromatography, since both share similar physicochemical properties, but its applicability with ultraviolet absorbance-based detectors is limited. In this work, a reference method using acetonitrile and high-performance liquid chromatography coupled to an ultraviolet photodiode array detector coupled to a corona charged aerosol detector system was developed to fingerprint a complex sample. The possibility of effectively substituting acetonitrile with acetone was investigated. Design of experiments was adopted to maximize the number of peaks acquired in both fingerprint developments. The methods with acetonitrile or acetone were successfully optimized and proved to be statistically similar when only the number of peaks or peak capacity was taken into consideration. However, the superiority of the latter was evidenced when parameters of separation and those related to greenness were heuristically combined. A green, comprehensive, time-and resource-saving approach is presented here, which is generic and applicable to other complex matrices. Furthermore, it is in line with environmental legislation and analytical trends.en
dc.description.affiliationUniversity of Tasmania, School of PhysicalSciences, Australian Centre for Researchon Separation Science(ACROSS), Hobart, Tas, Australia
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Instituto de Química (IQ), Araraquara, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agronômicas, Botucatu, SP, Brasil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Departamento de Química, São Carlos, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Instituto de Química (IQ), Araraquara, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agronômicas, Botucatu, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAustralian Research Council (ARC)
dc.description.sponsorshipARC Future Fellowship
dc.description.sponsorshipIdFAPESP: 2013/07600-3
dc.description.sponsorshipIdC.S.F.: 2012/15844-7
dc.format.extent1458-1465
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/jssc.201401324/abstract
dc.identifier.citationJournal Of Separation Science. Weinheim: Wiley-v C H Verlag Gmbh, v. 38, n. 9, p. 1458-1465, 2015.
dc.identifier.doi10.1002/jssc.201401324
dc.identifier.issn1615-9306
dc.identifier.lattes2518006820764120
dc.identifier.urihttp://hdl.handle.net/11449/129629
dc.identifier.wosWOS:000354371500003
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Separation Science
dc.relation.ispartofjcr2.415
dc.relation.ispartofsjr0,795
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCorona charged aerosol detectoren
dc.subjectGreen chromatographyen
dc.subjectLippia albaen
dc.subjectMetabolite profilingen
dc.subjectSolvent replacementen
dc.titleAcetone as a greener alternative to acetonitrile in liquid chromatographic fingerprintingen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes2518006820764120[4]
unesp.author.orcid0000-0001-8214-9957[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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