Metal Nanoparticles to Combat Candida albicans Infections: An Update

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dc.contributor.authorCarmo, Paulo Henrique Fonseca do [UNESP]
dc.contributor.authorGarcia, Maíra Terra [UNESP]
dc.contributor.authorFigueiredo-Godoi, Lívia Mara Alves [UNESP]
dc.contributor.authorLage, Anna Carolina Pinheiro
dc.contributor.authorSilva, Newton Soares da [UNESP]
dc.contributor.authorJunqueira, Juliana Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFiocruz Minas Gerais
dc.date.accessioned2023-07-29T16:03:55Z
dc.date.available2023-07-29T16:03:55Z
dc.date.issued2023-01-01
dc.description.abstractCandidiasis is an opportunistic mycosis with high annual incidence worldwide. In these infections, Candida albicans is the chief pathogen owing to its multiple virulence factors. C. albicans infections are usually treated with azoles, polyenes and echinocandins. However, these antifungals may have limitations regarding toxicity, relapse of infections, high cost, and emergence of antifungal resistance. Thus, the development of nanocarrier systems, such as metal nanoparticles, has been widely investigated. Metal nanoparticles are particulate dispersions or solid particles 10–100 nm in size, with unique physical and chemical properties that make them useful in biomedical applications. In this review, we focus on the activity of silver, gold, and iron nanoparticles against C. albicans. We discuss the use of metal nanoparticles as delivery vehicles for antifungal drugs or natural compounds to increase their biocompatibility and effectiveness. Promisingly, most of these nanoparticles exhibit potential antifungal activity through multi-target mechanisms in C. albicans cells and biofilms, which can minimize the emergence of antifungal resistance. The cytotoxicity of metal nanoparticles is a concern, and adjustments in synthesis approaches or coating techniques have been addressed to overcome these limitations, with great emphasis on green synthesis.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp), SP
dc.description.affiliationInstituto René Rachou Fiocruz Minas Gerais, MG
dc.description.affiliationDepartment of Environmental Engineering Institute of Science and Technology São Paulo State University (Unesp), SP
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp), SP
dc.description.affiliationUnespDepartment of Environmental Engineering Institute of Science and Technology São Paulo State University (Unesp), SP
dc.description.sponsorshipOffice of Naval Research Global
dc.description.sponsorshipIdOffice of Naval Research Global: ONRglobal N62909-20-1-2034
dc.identifierhttp://dx.doi.org/10.3390/microorganisms11010138
dc.identifier.citationMicroorganisms, v. 11, n. 1, 2023.
dc.identifier.doi10.3390/microorganisms11010138
dc.identifier.issn2076-2607
dc.identifier.scopus2-s2.0-85146763952
dc.identifier.urihttp://hdl.handle.net/11449/249593
dc.language.isoeng
dc.relation.ispartofMicroorganisms
dc.sourceScopus
dc.subjectantifungal agent
dc.subjectCandida albicans
dc.subjectgold
dc.subjectiron
dc.subjectmetal nanoparticles
dc.subjectsilver
dc.titleMetal Nanoparticles to Combat Candida albicans Infections: An Updateen
dc.typeResenha
unesp.author.orcid0000-0003-3186-885X[1]
unesp.author.orcid0000-0003-1663-369X[4]
unesp.author.orcid0000-0001-6452-9278[5]
unesp.author.orcid0000-0001-6646-6856[6]

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