Assessment of Female Reproductive Endpoints in Sprague-Dawley Rats Developmentally Exposed to Diuron: Potential Ovary Toxicity

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dc.contributor.authorGrassi, Tony Fernando [UNESP]
dc.contributor.authorGuerra, Marina Trevisan
dc.contributor.authorPerobelli, Juliana Elaine
dc.contributor.authorde Toledo, Fabiola Choqueta [UNESP]
dc.contributor.authorda Silva, Denise Salioni [UNESP]
dc.contributor.authorKempinas, Wilma de Grava [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:52:19Z
dc.date.available2014-05-20T13:52:19Z
dc.date.issued2011-10-01
dc.description.abstractBACKGROUND: Diuron is widely used in agriculture but its deleterious effects on the reproductive system and mammary gland are still poorly understood. This study evaluated whether early-life-stage exposure to Diuron alters puberty onset or susceptibility to mammary carcinogenesis in female Sprague-Dawley rats. METHODS and RESULTS: Pregnant rats received basal diet or diet containing Diuron at 500, 750, and 1,250 ppm, from gestational day 12 to the end of lactation (postnatal day 21 [PND21]). After weaning, female offspring continued receiving basal diet or diet containing Diuron until PND 51. At PND 51, female Sprague-Dawley offspring received a single dose of 50 mg/kg b.w. of 7,12-dimethylbenz(a) anthracene (DMBA) for initiation of mammary carcinogenesis. The animals were sacrificed on PND 51, 75, and 226 to 233 (week 25) for mammary gland morphology, reproductive organs and tumor analysis, respectively. There were no significant differences among groups on vaginal opening, estrous cycle, mammary morphology, or carcinogenesis. However, reductions in ovary weight and corpora lutea were observed at PND 75 in the group treated with Diuron at 1,250 ppm. CONCLUSIONS: The findings suggesting that Diuron exposure (1,250 ppm) may have been potentially toxic to the ovaries. Birth Defects Res (Part B) 92:478-486, 2011. (C) 2011 Wiley Periodicals, Inc.en
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Med, Dept Pathol, BR-18618970 São Paulo, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Post Grad Program Cellular & Struct Biol, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Morfol, Inst Biociencias, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sch Med, Dept Pathol, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Morfol, Inst Biociencias, BR-18618970 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 06/01330-0
dc.format.extent478-486
dc.identifierhttp://dx.doi.org/10.1002/bdrb.20317
dc.identifier.citationBirth Defects Research Part B-developmental and Reproductive Toxicology. Malden: Wiley-blackwell, v. 92, n. 5, p. 478-486, 2011.
dc.identifier.doi10.1002/bdrb.20317
dc.identifier.issn1542-9733
dc.identifier.lattes6326450271169741
dc.identifier.lattes3278528112652257
dc.identifier.urihttp://hdl.handle.net/11449/18702
dc.identifier.wosWOS:000296612100008
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofBirth Defects Research Part B: Developmental and Reproductive Toxicology
dc.relation.ispartofjcr1.244
dc.relation.ispartofsjr0,515
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdiuronen
dc.subjectmaternal exposureen
dc.subjectfemale offspringen
dc.subjectreproductionen
dc.subjectmammary carcinogenesisen
dc.subjectSprague-Dawley ratsen
dc.titleAssessment of Female Reproductive Endpoints in Sprague-Dawley Rats Developmentally Exposed to Diuron: Potential Ovary Toxicityen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes6326450271169741
unesp.author.lattes3278528112652257[7]
unesp.author.orcid0000-0002-2718-1564[1]
unesp.author.orcid0000-0002-2112-5123[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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