Polycation-Based Gene Therapy: Current Knowledge and New Perspectives

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dc.contributor.authorTiera, Marcio J. [UNESP]
dc.contributor.authorShi, Qin
dc.contributor.authorWinnik, Francoise M.
dc.contributor.authorFernandes, Julio C.
dc.contributor.institutionUniv Montreal
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:03:06Z
dc.date.available2014-05-20T14:03:06Z
dc.date.issued2011-08-01
dc.description.abstractAt present, gene transfection insufficient efficiency is a major drawback of non-viral gene therapy. The 2 main types of delivery systems deployed in gene therapy are based on viral or non-viral gene carriers. Several non-viral modalities can transfer foreign genetic material into the human body. To do so, polycation-based gene delivery methods must achieve sufficient efficiency in the transportation of therapeutic genes across various extracellular and intracellular barriers. These barriers include interactions with blood components, vascular endothelial cells and uptake by the reticuloendothelial system. Furthermore, the degradation of therapeutic DNA by serum nucleases is a potential obstacle for functional delivery to target cells. Cationic polymers constitute one of the most promising approaches to the use of viral vectors for gene therapy. A better understanding of the mechanisms by which DNA can escape from endosomes and traffic to enter the nucleus has triggered new strategies of synthesis and has revitalized research into new polycation-based systems. The objective of this review is to address the state of the art in gene therapy with synthetic and natural polycations and the latest advances to improve gene transfer efficiency in cells.en
dc.description.affiliationUniv Montreal, Hop Sacre Coeur, Orthoped Res Lab, Montreal, PQ H4J 1C5, Canada
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Quim & Ciencias Ambientais, Sao Jose do Rio Preto, Brazil
dc.description.affiliationUniv Montreal, Fac Pharm, Montreal, PQ H4J 1C5, Canada
dc.description.affiliationUniv Montreal, Dept Chem, Montreal, PQ H4J 1C5, Canada
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Quim & Ciencias Ambientais, Sao Jose do Rio Preto, Brazil
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR)
dc.description.sponsorshipFonds de la recherche en sante du Quebec
dc.description.sponsorshipUNESP-Brazil
dc.description.sponsorshipIdCHIR: CCL-92212
dc.description.sponsorshipIdCHIR: CCL-99636
dc.description.sponsorshipIdCHIR: CCM 104888
dc.format.extent288-306
dc.identifier.citationCurrent Gene Therapy. Sharjah: Bentham Science Publ Ltd, v. 11, n. 4, p. 288-306, 2011.
dc.identifier.issn1566-5232
dc.identifier.urihttp://hdl.handle.net/11449/22237
dc.identifier.wosWOS:000294342300004
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Gene Therapy
dc.relation.ispartofjcr1.943
dc.relation.ispartofsjr0,951
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDNAen
dc.subjectGene therapyen
dc.subjectnanoparticlesen
dc.subjectpolycationsen
dc.subjectPolymersen
dc.titlePolycation-Based Gene Therapy: Current Knowledge and New Perspectivesen
dc.typeResenha
dcterms.rightsHolderBentham Science Publ Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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