In vitro cytotoxic activity of Baccharis dracunculifolia and propolis against HEp-2 cells

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dc.contributor.authorBufalo, M. C. [UNESP]
dc.contributor.authorCandeias, J. M. G. [UNESP]
dc.contributor.authorSousa, J. P. B.
dc.contributor.authorBastos, J. K.
dc.contributor.authorSforcin, J. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:50:59Z
dc.date.available2014-05-20T13:50:59Z
dc.date.issued2010-01-01
dc.description.abstractBaccharis dracunculifolia is the most important vegetal source of propolis in southeast Brazil, and researchers have been investigating its biological properties. Propolis is a complex resinous hive product collected by bees from several plants, showing a very complex chemical composition. It has been employed since ancient times due to its therapeutic properties, such as antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antitumour activities, among others. The goal of this work was to compare the cytotoxic action of B. dracunculifolia, propolis and two isolated compounds (caffeic and cinnamic acids) on human laryngeal epidermoid carcinoma (HEp-2) cells in vitro. These cells were incubated with different concentrations of each variable, and cell viability was assessed by the crystal violet method. Lower concentrations of B. dracunculifolia (extract and essential oil), propolis, as well as caffeic and cinnamic acids, showed no cytotoxic activity against HEp-2 cells. on the other hand, elevated concentrations (50 and 100 mu g per 100 mu L) exerted a cytotoxic action, and propolis showed a more efficient action than its vegetal source and isolated compounds. Further investigation is still needed in order to explore the potential of these variables as antitumour agents and to understand their mechanisms of action.en
dc.description.affiliationUniv Estadual Paulista, Dept Microbiol & Immunol, Biosci Inst, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Pharmaceut Sci, Sch Pharmaceut Sci Ribeirao Preto, Lab Pharmacognosy, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Microbiol & Immunol, Biosci Inst, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/13005-1
dc.description.sponsorshipIdFAPESP: 06/59893-0
dc.format.extent1710-1718
dc.identifierhttp://dx.doi.org/10.1080/14786410902909300
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 24, n. 18, p. 1710-1718, 2010.
dc.identifier.doi10.1080/14786410902909300
dc.identifier.issn1478-6419
dc.identifier.orcid0000-0003-1515-702X
dc.identifier.urihttp://hdl.handle.net/11449/18199
dc.identifier.wosWOS:000283687900006
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.relation.ispartofjcr1.928
dc.relation.ispartofsjr0,671
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpropolisen
dc.subjectBaccharis dracunculifoliaen
dc.subjectHEp-2 cellsen
dc.subjectantitumour actionen
dc.titleIn vitro cytotoxic activity of Baccharis dracunculifolia and propolis against HEp-2 cellsen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
unesp.author.orcid0000-0003-1515-702X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB