Neurotoxicity associated with chronic exposure to dichlorophenoxyacetic acid (2,4-D)–a simulation of environmental exposure in adult rats

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dc.contributor.authorUeda, Rose Meire R.
dc.contributor.authorde Souza, Verena M.
dc.contributor.authorMagalhães, Letícia R.
dc.contributor.authorChagas, Pedro Henrique N.
dc.contributor.authorVeras, Allice S. C. [UNESP]
dc.contributor.authorTeixeira, Giovana R. [UNESP]
dc.contributor.authorNai, Gisele A.
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T11:02:17Z
dc.date.available2021-06-25T11:02:17Z
dc.date.issued2021-01-01
dc.description.abstractThe herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is the second most widely used herbicide in the world. The objective of this study was to evaluate the neurotoxic effects and the possible role of the dysregulation of apoptosis in the genesis of brain damage in chronic exposure to 2,4-D in rats. Eighty adult male rats were distributed into eight groups (n = 10) and exposed orally (contaminated feed) and via inhalation, with two groups exposed to distilled water (control) and six to 2,4-D in three distinct concentrations. They were exposed for 6 months. A neurobehavioral assessment was performed, and the brain was collected for histopathology and immunohistochemistry. The animals in the control groups showed greater motility in the open-field test and a greater number of entries in the elevated-plus-maze test than those exposed to 2,4-D (p < 0.05). Neuronal necrosis was more incident in animals exposed to 2,4-D (p < 0.05). There was a negative correlation between the expression of BAX and the measurement of the cerebral cortex thickness (r = −0.713; p = 0.047). Regardless of the route of exposure, 2,4-D led to a deficit in neurobehavioral tests and decreased thickness of the cerebral cortex associated with increased expression of the pro-apoptotic protein BAX.en
dc.description.affiliationFaculty of Psychology Universidade do Oeste Paulista (UNOESTE)
dc.description.affiliationFaculty of Medicine Universidade do Oeste Paulista (UNOESTE)
dc.description.affiliationDepartment of Physical Education Faculdade de Ciências e Tecnologia Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP
dc.description.affiliationDepartment of Pathology and Graduate Program in Animal Science Universidade do Oeste Paulista (UNOESTE)
dc.description.affiliationUnespDepartment of Physical Education Faculdade de Ciências e Tecnologia Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP
dc.identifierhttp://dx.doi.org/10.1080/03601234.2021.1939622
dc.identifier.citationJournal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes.
dc.identifier.doi10.1080/03601234.2021.1939622
dc.identifier.issn1532-4109
dc.identifier.issn0360-1234
dc.identifier.scopus2-s2.0-85107747863
dc.identifier.urihttp://hdl.handle.net/11449/207861
dc.language.isoeng
dc.relation.ispartofJournal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
dc.sourceScopus
dc.subjectbehavior
dc.subjectcell cycle
dc.subjectCentral nervous system
dc.subjectenvironment
dc.subjectpesticides
dc.titleNeurotoxicity associated with chronic exposure to dichlorophenoxyacetic acid (2,4-D)–a simulation of environmental exposure in adult ratsen
dc.typeArtigo
unesp.author.orcid0000-0003-1674-7371[7]

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