Triiodothyronine (T3) does not induce rankl expression in rat ROS 17/2.8 Cells

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dc.contributor.authorSaraiva, Patrícia P. [UNESP]
dc.contributor.authorTeixeira, Silvania S. [UNESP]
dc.contributor.authorNogueira, Célia Regina [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:38:58Z
dc.date.available2022-04-28T20:38:58Z
dc.date.issued2008-01-01
dc.description.abstractOsteoclastogenesis may be regulated via activation of the RANK/RANKL (receptor activator of nuclear factor-kappa B/ receptor activator of nuclear factor-kappa B ligand) system, which Is mediated by osteoblasts. However, the bone loss mechanism induced by T3 (triiodothyronine) is still controversial. In this study, osteoblastic lineage rat cells (ROS 17/2.8) were treated with T3 (10-8M, 10-9M, and 10-10M), and RANKL mRNA (messenger RNA) expression was measured by semiquantitative RT-PCR. Our results show that T3 concentrations used did not significantly enhance RANKL expression compared to controls without hormone treatment. This data suggests that other mechanisms, unrelated to the RANK/RANKL system, might be to activate osteoclast differentiation in these cells. copyright © ABE&M todos os direitos reservados.en
dc.description.affiliationDepartment of Medical Clinical Botucatu School of Medicine Sao Paulo State University (Unesp), Botucatu, SP
dc.description.affiliationDepartment of Biostatistics Botucatu School of Medicine Sao Paulo State University (Unesp), Botucatu, SR
dc.description.affiliationUnespDepartment of Medical Clinical Botucatu School of Medicine Sao Paulo State University (Unesp), Botucatu, SP
dc.description.affiliationUnespDepartment of Biostatistics Botucatu School of Medicine Sao Paulo State University (Unesp), Botucatu, SR
dc.format.extent109-113
dc.identifierhttp://dx.doi.org/10.1590/S0004-27302008000100015
dc.identifier.citationArquivos Brasileiros de Endocrinologia e Metabologia, v. 52, n. 1, p. 109-113, 2008.
dc.identifier.doi10.1590/S0004-27302008000100015
dc.identifier.issn1677-9487
dc.identifier.issn0004-2730
dc.identifier.scopus2-s2.0-41149119567
dc.identifier.urihttp://hdl.handle.net/11449/225076
dc.language.isoeng
dc.relation.ispartofArquivos Brasileiros de Endocrinologia e Metabologia
dc.sourceScopus
dc.subjectBone
dc.subjectRANKL
dc.subjectRat
dc.subjectROS17/2.8 cell
dc.subjectThyroid hormone
dc.titleTriiodothyronine (T3) does not induce rankl expression in rat ROS 17/2.8 Cellsen
dc.typeArtigo

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