Time-dependent effects of lead on rat reproductive functions

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dc.contributor.authorKempinas, W. G. [UNESP]
dc.contributor.authorFavaretto, A. L. V.
dc.contributor.authorMelo, V. R.
dc.contributor.authorCarvalho, T. L. L.
dc.contributor.authorPetenusci, S. O.
dc.contributor.authorOliveira, R. M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:19:43Z
dc.date.available2014-05-20T15:19:43Z
dc.date.issued1994-11-01
dc.description.abstractThe effects of exposure to lead on endocrine function and the reproductive parameters were studied in pubertal rats treated with 1.0 g l(-1) lead acetate in drinking water for 20 days (subacute group) or 9 months (chronic group) in addition to i.v. injections of lead acetate (0.1 mg 100 g(-1) body wt.) every 10 (subacute group) or 15 days (chronic group). Although basal levels of testosterone were higher both in plasma and in testes of acutely intoxicated animals, the circulating levels of luteinizing hormone (LH) were not affected in either group, nor was the LH-releasing hormone content of the median eminence. The density of [I-125]LH/human chorionic gonadotrophin (hCG) binding sites in testicular homogenates was reduced by saturnism in both groups, concomitant with a significantly increased apparent affinity constant of the hormone-receptor complex. These data can be viewed as the result of a mixture of specific lead toxicity (e.g. at the enzyme level) with other more general actions (e.g. at the level of the hypothalamus-pituitary-testicular axis).en
dc.description.affiliationUNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FISIOL,BR-14049 RIBEIRAO PRET,SP,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT MORPHOL,BR-14049 RIBEIRAO PRET,SP,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC ODONTOL,DEPT ESTOMATOL,BR-14049 RIBEIRAO PRET,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FAC ODONTOL,DEPT FISIOL,BR-14049 RIBEIRAO PRET,BRAZIL
dc.description.affiliationUNIV FED SAO CARLOS,INST CIENCIAS BIOMED,DEPT FARMACOL,BR-05508 SAO PAULO,SP,BRAZIL
dc.description.affiliationUnespDepartamento de Morfologia, Instituto de Biociências, Universidade Estadual Paulista, 18618-000, Botucatu, SP, Brazil
dc.format.extent427-433
dc.identifierhttp://dx.doi.org/10.1002/jat.2550140608
dc.identifier.citationJournal of Applied Toxicology. W Sussex: John Wiley & Sons Ltd, v. 14, n. 6, p. 427-433, 1994.
dc.identifier.doi10.1002/jat.2550140608
dc.identifier.issn0260-437X
dc.identifier.lattes6326450271169741
dc.identifier.urihttp://hdl.handle.net/11449/31114
dc.identifier.wosWOS:A1994PW36400007
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Applied Toxicology
dc.relation.ispartofjcr2.909
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLEAD EXPOSUREpt
dc.subjectTESTISpt
dc.subjectTESTOSTERONEpt
dc.subjectHYPOTHALAMUS-PITUITARY-TESTICULAR AXISpt
dc.subjectSEMINAL VESICLEpt
dc.subjectRATpt
dc.titleTime-dependent effects of lead on rat reproductive functionsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes6326450271169741
unesp.author.orcid0000-0002-2112-5123[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Morfologia - IBB