Genome-Wide Association Study for Indicator Traits of Sexual Precocity in Nellore Cattle

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dc.contributor.authorIrano, Natalia [UNESP]
dc.contributor.authorFerreira de Camargo, Gregorio Miguel [UNESP]
dc.contributor.authorCosta, Raphael Bermal [UNESP]
dc.contributor.authorNascimento Terakado, Ana Paula [UNESP]
dc.contributor.authorBraga Magalhaes, Ana Fabricia [UNESP]
dc.contributor.authorOliveira Silva, Rafael Medeiros de [UNESP]
dc.contributor.authorDias, Marina Mortati [UNESP]
dc.contributor.authorBignardi, Annaiza Braga
dc.contributor.authorBaldi, Fernando [UNESP]
dc.contributor.authorCarvalheiro, Roberto [UNESP]
dc.contributor.authorOliveira, Henrique Nunes de [UNESP]
dc.contributor.authorAlbuquerque, Lucia Galvao de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.date.accessioned2018-11-26T16:54:58Z
dc.date.available2018-11-26T16:54:58Z
dc.date.issued2016-08-05
dc.description.abstractThe objective of this study was to perform a genome-wide association study (GWAS) to detect chromosome regions associated with indicator traits of sexual precocity in Nellore cattle. Data from Nellore animals belonging to farms which participate in the DeltaGen (R) and Paint (R) animal breeding programs, were used. The traits used in this study were the occurrence of early pregnancy (EP) and scrotal circumference (SC). Data from 72,675 females and 83,911 males with phenotypes were used; of these, 1,770 females and 1,680 males were genotyped. The SNP effects were estimated with a single-step procedure (WssGBLUP) and the observed phenotypes were used as dependent variables. All animals with available genotypes and phenotypes, in addition to those with only phenotypic information, were used. A single-trait animal model was applied to predict breeding values and the solutions of SNP effects were obtained from these breeding values. The results of GWAS are reported as the proportion of variance explained by windows with 150 adjacent SNPs. The 10 windows that explained the highest proportion of variance were identified. The results of this study indicate the polygenic nature of EP and SC, demonstrating that the indicator traits of sexual precocity studied here are probably controlled by many genes, including some of moderate effect. The 10 windows with large effects obtained for EP are located on chromosomes 5, 6, 7, 14, 18, 21 and 27, and together explained 7.91% of the total genetic variance. For SC, these windows are located on chromosomes 4, 8, 11, 13, 14, 19, 22 and 23, explaining 6.78% of total variance. GWAS permitted to identify chromosome regions associated with EP and SC. The identification of these regions contributes to a better understanding and evaluation of these traits, and permits to indicate candidate genes for future investigation of causal mutations.en
dc.description.affiliationUniv Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Ciencias Agr & Tecnol, Grp Melhoramento Anim Mato Grosso, Rondonopolis, MG, Brazil
dc.description.affiliationUniv Fed Bahia, Dept Med Vet Prevent & Prod Anim, Escola Med Vet & Zootecnia, Salvador, BA, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2013/00848-0
dc.description.sponsorshipIdFAPESP: 2009/16118-5
dc.description.sponsorshipIdCNPq: 559631/2009-0
dc.format.extent14
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0159502
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 11, n. 8, 14 p., 2016.
dc.identifier.doi10.1371/journal.pone.0159502
dc.identifier.fileWOS000381369500009.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11449/161820
dc.identifier.wosWOS:000381369500009
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleGenome-Wide Association Study for Indicator Traits of Sexual Precocity in Nellore Cattleen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
unesp.author.orcid0000-0002-4506-0555[10]

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