Cervicovaginal levels of proinflammatory cytokines are increased during chlamydial infection in bacterial vaginosis but not in lactobacilli-dominated flora

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dc.contributor.authorMarconi, Camila [UNESP]
dc.contributor.authorSantos-Greatti, Mariana M.V. [UNESP]
dc.contributor.authorParada, Cristina M.G.L.
dc.contributor.authorPontes, Anagloria [UNESP]
dc.contributor.authorPontes, Ana G. [UNESP]
dc.contributor.authorGiraldo, Paulo C.
dc.contributor.authorDonders, Gilbert G.G.
dc.contributor.authorDa Silva, Márcia Guimarães [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity Hospital Gasthuisberg
dc.date.accessioned2018-12-11T16:56:15Z
dc.date.available2018-12-11T16:56:15Z
dc.date.issued2014-01-01
dc.description.abstractOBJECTIVE: The purpose of this study was to assess the cervicovaginal levels of proinflammatory cytokines in women with Chlamydia trachomatis (CT) infection in the presence of bacterial vaginosis (BV) and normal flora and to compare with those negative for CT. MATERIALS AND METHODS: In this cross-sectional study, nonpregnant women were enrolled at 2 outpatient clinics and at 1 primary medical care unit in São Paulo State, Brazil. Cervicovaginal samples from 256 women with BV, of which 68 (26.6%) had concomitant CT infection and 188 (73.4%) were CT-negative, were measured for interleukin-1β (IL-1β), IL-6, and IL-8 by enzyme-linked immunosorbent assay. A matching number of samples from women with normal flora, CT-positive (n = 68) and negative (n = 188), were evaluated as control. Cytokine levels were compared by Mann-Whitney test and differences were considered significant at p < .05. RESULTS: In CT-negative women, IL-1β was increased in BV (p < .001) when compared to normal flora, while the levels of IL-6 and IL8 were unchanged. The presence of CT infection was not associated with differences on cytokine levels in women with normal flora. However, women with BV had higher levels of IL-1β (p = .02), IL-6 (p = .02), and IL-8 (p = .03) in the presence of CT when compared to those who tested negative for CT. CONCLUSIONS: Detection of endocervical CT is associated with increased cervicovaginal IL-1β, IL-6, and IL-8 levels in women with concomitant BV but not in those with normal flora. © 2014, American Society for Colposcopy and Cervical Pathology.en
dc.description.affiliationDepartment of Pathology, Botucatu Medical School, Distrito de Rubião Junior, s/n, Botucatu, São Paulo 18618-970
dc.description.affiliationDepartment of Nursing, Campinas
dc.description.affiliationDepartment of Gynecology and Obstetrics, Botucatu Medical School, UNESP - Univ Estadual Paulista, Campinas
dc.description.affiliationDepartment of Gynecology and Obstetrics, Faculdade de Ciências Médicas, Campinas University, Campinas
dc.description.affiliationUniversity Hospital Gasthuisberg, Leuven
dc.description.affiliationUnespDepartment of Pathology, Botucatu Medical School, Distrito de Rubião Junior, s/n, Botucatu, São Paulo 18618-970
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics, Botucatu Medical School, UNESP - Univ Estadual Paulista, Campinas
dc.format.extent261-265
dc.identifierhttp://dx.doi.org/10.1097/LGT.0000000000000003
dc.identifier.citationJournal of Lower Genital Tract Disease, v. 18, n. 3, p. 261-265, 2014.
dc.identifier.doi10.1097/LGT.0000000000000003
dc.identifier.issn1526-0976
dc.identifier.issn1089-2591
dc.identifier.scopus2-s2.0-84903819969
dc.identifier.urihttp://hdl.handle.net/11449/171617
dc.language.isoeng
dc.relation.ispartofJournal of Lower Genital Tract Disease
dc.relation.ispartofsjr0,602
dc.relation.ispartofsjr0,602
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectbacterial vaginosis
dc.subjectChlamydia trachomatis
dc.subjectcytokine
dc.subjectendocervicitis
dc.titleCervicovaginal levels of proinflammatory cytokines are increased during chlamydial infection in bacterial vaginosis but not in lactobacilli-dominated floraen
dc.typeArtigo

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