Comparison of oxidative stress in ASA physical status I patients scheduled for minimally invasive surgery under balanced or intravenous anesthesia

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dc.contributor.authorBraz, M. G. [UNESP]
dc.contributor.authorBraz, L. G. [UNESP]
dc.contributor.authorBraz, J. R. [UNESP]
dc.contributor.authorPierine, D. T. [UNESP]
dc.contributor.authorCorrea, C. R. [UNESP]
dc.contributor.authorFerreira, A. L. [UNESP]
dc.contributor.authorCarvalho, L. R. [UNESP]
dc.contributor.authorYeum, K. J.
dc.contributor.authorSalvadori, D. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionTufts University
dc.contributor.institutionKonkuk University
dc.date.accessioned2022-04-29T07:12:46Z
dc.date.available2022-04-29T07:12:46Z
dc.date.issued2013-09-01
dc.description.abstractBackground. The effects of anesthetics on inflammation and oxidative parameters, evaluated in patients without comorbidities undergoing minor surgery, remain unknown. The present study aimed to investigate the inflammatory and oxidative stress status in adult patients undergoing elective minimally invasive surgery, using different anesthetic techniques. Methods. Thirty patients classified as ASA physical status I, who were scheduled for minor surgeries (tympanoplasty or septoplasty), were randomly allocated into two groups: balanced (BAL) anesthesia maintained with isoflurane or total intravenous anesthesia (TIVA) with propofol. Blood samples were drawn prior to the induction of anesthesia (baseline), 120 min after the beginning of anesthesia and one day after surgery. The proinflammatory cytokine IL-6 was determined by flow cytometry; DNA oxidation was evaluated by the single cell gel electrophoresis assay, and plasma malondialdehyde (lipid peroxidation biomarker) and antioxidant status were determined through fluorometry. Results. Increased IL-6 was observed one day after surgery in both groups (P=0.0001). Malondialdehyde levels did not change among the time points assessed or between the groups (P>0.05). Whereas BAL anesthesia had no effect on acid nucleic and antioxidant status, TIVA decreased oxidized/alkylated purines (P=0.03) and increased antioxidant status (P=0.002) during anesthesia. The two groups did not differ significantly in DNA oxidation or antioxidant status (P>0.05). Conclusion. BAL anesthesia maintained with isoflurane and TIVA maintained with propofol are safe by virtue of not causing oxidative stress status in ASA physical status I patients undergoing minimally invasive surgeries. Moreover, even in minor surgeries, TIVA with propofol produces an antioxidant effect in patients.en
dc.description.affiliationDepartment of Anesthesiology Faculdade de Medicina de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.description.affiliationDepartment of Pathology Faculdade de Medicina de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.description.affiliationDepartment of Internal Medicine Faculdade de Medicina de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.description.affiliationDepartment of Biostatistics Instituto de Biociencias de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.description.affiliationJean Mayer USDA-Human Nutrition Research Center on Aging Tufts University, Boston, MA
dc.description.affiliationCollege of Biomedical and Health Sciences Konkuk University, Konkuk
dc.description.affiliationUnespDepartment of Anesthesiology Faculdade de Medicina de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartment of Pathology Faculdade de Medicina de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartment of Internal Medicine Faculdade de Medicina de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartment of Biostatistics Instituto de Biociencias de Botucatu UNESP - Univ Estadual Paulista, Botucatu, SP
dc.format.extent1030-1038
dc.identifier.citationMinerva Anestesiologica, v. 79, n. 9, p. 1030-1038, 2013.
dc.identifier.issn0375-9393
dc.identifier.scopus2-s2.0-84888791218
dc.identifier.urihttp://hdl.handle.net/11449/227337
dc.language.isoeng
dc.relation.ispartofMinerva Anestesiologica
dc.sourceScopus
dc.subjectAnesthetics
dc.subjectAntioxidant agents
dc.subjectGeneral surgery
dc.subjectInflammation
dc.titleComparison of oxidative stress in ASA physical status I patients scheduled for minimally invasive surgery under balanced or intravenous anesthesiaen
dc.typeArtigo

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Artigos - Anestesiologia - FMB
Artigos - Bioestatística - IBB
Artigos - Clínica Médica - FMB
Artigos - Patologia - FMB