The effect of elevated blood cortisol levels on the extinction of a conditioned stress response in rainbow trout

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dc.contributor.authorBarreto, R. E.
dc.contributor.authorVolpato, G. L.
dc.contributor.authorPottinger, T. G.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLancaster Environhm Ctr
dc.date.accessioned2014-05-20T13:49:45Z
dc.date.available2014-05-20T13:49:45Z
dc.date.issued2006-09-01
dc.description.abstractFollowing previously published observations that a conditioned response (CR) was lost more quickly by rainbow trout (Oncorhynchus mykiss) exhibiting a high responsiveness to stressors than by low responding individuals this study was designed to investigate the effects of exogenous cortisol on the retention of a CR in unselected rainbow trout. Fish held in isolation were conditioned over a 10-day period by pairing an innocuous signal (conditioned stimulus, CS: a water jet played on the surface of the tank water) with a mild stressor (unconditioned stimulus, US: 30 min of confinement). This resulted in a brief elevation of plasma cortisol levels (the CR) when the fish was exposed to the CS only. The effect of exogenous cortisol on the retention of the CR was evaluated by comparing the performance of fish that received cortisol-containing slow-release intraperitoneal implants, with fish receiving vehicle-only implants. Retention of the CR was assessed at intervals up to 35 days after conditioning ceased. The CR was considered to be evident when 30 min following presentation of the CS, mean plasma cortisol levels were significantly higher in conditioned than untrained fish. on day 1 both cortisol-implanted and vehicle-implanted conditioned fish exhibited a CR. However, from day 5 onwards the CR was observed only in the vehicle-implanted and conditioned group. This finding indicates that administration of cortisol accelerated the extinction of the CR in the cortisol-implanted fish, suggesting that elevated plasma cortisol levels can impair memory processes in rainbow trout. (c) 2006 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Fisiol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationLancaster Environhm Ctr, Ctr Ecol & Hydrol, Lancaster LA1 4AP, England
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Fisiol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.format.extent484-488
dc.identifierhttp://dx.doi.org/10.1016/j.yhbeh.2006.06.017
dc.identifier.citationHormones and Behavior. San Diego: Academic Press Inc. Elsevier B.V., v. 50, n. 3, p. 484-488, 2006.
dc.identifier.doi10.1016/j.yhbeh.2006.06.017
dc.identifier.issn0018-506X
dc.identifier.lattes3363114201357959
dc.identifier.urihttp://hdl.handle.net/11449/17743
dc.identifier.wosWOS:000240242600017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofHormones and Behavior
dc.relation.ispartofjcr4.418
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectstresspt
dc.subjectexogenous cortisolpt
dc.subjectmemorypt
dc.subjectPavlovian conditioningpt
dc.subjectOncorhynchus mykisspt
dc.subjectfishpt
dc.titleThe effect of elevated blood cortisol levels on the extinction of a conditioned stress response in rainbow trouten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3363114201357959
unesp.author.orcid0000-0001-7661-9369[3]
unesp.author.orcid0000-0002-4611-0059[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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