Pulpal and periodontal diseases increase triglyceride levels in diabetic rats

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dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.authorda Silva Facundo, Aguinaldo Cândido [UNESP]
dc.contributor.authorAzuma, Mariane Maffei [UNESP]
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.contributor.authorAstolphi, Rafael Dias [UNESP]
dc.contributor.authorBomfim, Suely Regina Mogami [UNESP]
dc.contributor.authorNarciso, Luís Gustavo [UNESP]
dc.contributor.authorGomes-Filho, João Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:27Z
dc.date.available2014-05-27T11:27:27Z
dc.date.issued2013-01-01
dc.description.abstractObjectives: The aim of this study was to evaluate triglyceride and cholesterol levels in diabetic rats and their relationship with pulpal and periodontal diseases. Methods: Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into the following eight groups comprising ten animals each: normal rats (G1), rats with pulpal diseases (G2), rats with periodontal diseases (G3), rats with both pulpal and periodontal diseases (G4), diabetic rats (G5), diabetic rats with pulpal diseases (G6), diabetic rats with periodontal diseases (G7), and diabetic rats with both periodontal and pulpal diseases (G8). Diabetes was induced by injecting streptozotocin, periapical lesions were induced by exposing pulpal tissue to the oral environment, and periodontal diseases were induced by periodontal ligature. The animals were killed after 30 days, and lipid profile was enzymatically measured using Trinder's method. The total assessed values were statistically analyzed by analysis of variance and Tukey test (p < 0.05). Results: The triglyceride levels of diabetic rats with periodontal disease and of diabetic rats with both periodontal and pulpal diseases were significantly higher than those of normal rats and nondiabetic group rats, respectively. The differences in the cholesterol levels among the groups were not significant. Conclusions: We found that the association of pulpal and periodontal diseases with diabetes increased triglyceride levels in rats. Clinical significance: Changes in lipid profile may be related to the presence of oral infections and diabetes. © 2012 Springer-Verlag Berlin Heidelberg.en
dc.description.affiliationEndodontics, Araçatuba Dental School UNESP-Univ Estadual Paulista, R. José Bonifácio, Araçatuba, 1193 São Paulo
dc.description.affiliationBasic Science, Araçatuba Dental School UNESP-Univ Estadual Paulista, Araçatuba, São Paulo
dc.description.affiliationClinic and Surgery and Animal Reproduction, Araçatuba Veterinary Medicine School UNESP-Univ Estadual Paulista, Araçatuba, São Paulo
dc.description.affiliationUnespEndodontics, Araçatuba Dental School UNESP-Univ Estadual Paulista, R. José Bonifácio, Araçatuba, 1193 São Paulo
dc.description.affiliationUnespBasic Science, Araçatuba Dental School UNESP-Univ Estadual Paulista, Araçatuba, São Paulo
dc.description.affiliationUnespClinic and Surgery and Animal Reproduction, Araçatuba Veterinary Medicine School UNESP-Univ Estadual Paulista, Araçatuba, São Paulo
dc.format.extent1595-1599
dc.identifierhttp://dx.doi.org/10.1007/s00784-012-0853-7
dc.identifier.citationClinical Oral Investigations, v. 17, n. 6, p. 1595-1599, 2013.
dc.identifier.doi10.1007/s00784-012-0853-7
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.lattes9235743081667362
dc.identifier.lattes8275401688702343
dc.identifier.scopus2-s2.0-84879463757
dc.identifier.urihttp://hdl.handle.net/11449/74122
dc.identifier.wosWOS:000320887800017
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.relation.ispartofjcr2.386
dc.relation.ispartofsjr0,986
dc.relation.ispartofsjr0,986
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCholesterol levels
dc.subjectDiabetes
dc.subjectLipid profile
dc.subjectOral infections
dc.subjectTriglyceride levels
dc.titlePulpal and periodontal diseases increase triglyceride levels in diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.lattes9235743081667362
unesp.author.lattes8275401688702343
unesp.author.orcid0000-0001-5994-2287[8]
unesp.author.orcid0000-0003-2348-7846[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Odontologia Restauradora - FOA
Artigos - Ciências Básicas - FOA
Artigos - Clínica, Cirurgia e Reprodução Animal - FMVA