Effects of long-term cyclosporin therapy on the periodontium of rats

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dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.authorSpolidorio, D. M.
dc.contributor.authorHolzhausen, M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:07Z
dc.date.available2014-05-27T11:21:07Z
dc.date.issued2004-08-01
dc.description.abstractBackground: The treatment of cyclosporin A triggers an early bone loss and gingival overgrowth. There is a lack of studies exploring the effects of long-term cyclosporin A therapy on alveolar bone homeostasis and gingival tissue. Objective: The purpose of this study was to evaluate the effects of long-term therapy with cyclosporin A on the gingival tissue and on the alveolar bone metabolism in rats. Materials and methods: Rats were treated for 60, 120, 180 and 240 days with a daily subcutaneous injection of 10 mg/kg body weight of cyclosporin A. At the end of experimental periods, animals were killed and the serum calcium (Ca2+) and alkaline phosphatase levels were measured in all groups. After histological processing, the oral epithelium and the connective tissue, as well as volume densities of alveolar bone (Vb) and multinucleated osteoclasts (Vo), were assessed at the region of the lower first molars. Results: Significant increases in the serum alkaline phosphatase were observed in those groups that received cyclosporin A therapy. After 60 and 120 days of the treatment with cyclosporin A, evident gingival overgrowth associated with a significant increase of epithelium and connective tissue was observed, as well as a decrease of the densities of bone and an increase of densities of osteoclasts. After 180 and 240 days of the treatment, there was a reduction of the gingival overgrowth associated with significant decreases of epithelium and connective tissue, as well as an increase of bone densities and a decrease of osteoclasts. Conclusion: Within the limits of this experimental study, it can be concluded that the deleterious periodontal effects of cyclosporin A administration may be time-related side-effects. © Blackwell Munksgaard, 2004.en
dc.description.affiliationDepartment of Oral Pathology Dental School, Araraquara Univ. of State of São Paulo, São Paulo
dc.description.affiliationDepartment of Periodontology Dental School, Araraquara Univ. of State of São Paulo, São Paulo
dc.description.affiliationDepartment of Pathology Univ. of State of São Paulo Dental School, R. Humaitá, 1680, C. P. 331, São Paulo, CEP: 14801-903
dc.format.extent257-262
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0765.2004.00734.x
dc.identifier.citationJournal of Periodontal Research, v. 39, n. 4, p. 257-262, 2004.
dc.identifier.doi10.1111/j.1600-0765.2004.00734.x
dc.identifier.issn0022-3484
dc.identifier.lattes2640929291808415
dc.identifier.scopus2-s2.0-3242811126
dc.identifier.urihttp://hdl.handle.net/11449/67818
dc.language.isoeng
dc.relation.ispartofJournal of Periodontal Research
dc.relation.ispartofjcr2.878
dc.relation.ispartofsjr0,927
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAlveolar bone loss
dc.subjectCyclosporin A
dc.subjectGingival overgrowth
dc.subjectalkaline phosphatase
dc.subjectcalcium ion
dc.subjectcyclosporin A
dc.subjectalveolar bone
dc.subjectanimal tissue
dc.subjectbone density
dc.subjectcalcium blood level
dc.subjectcell density
dc.subjectcontrolled study
dc.subjectenzyme blood level
dc.subjectgingiva overgrowth
dc.subjectlong term care
dc.subjectmale
dc.subjectnonhuman
dc.subjectosteoclast
dc.subjectperiodontium
dc.subjectrat
dc.subjectAlkaline Phosphatase
dc.subjectAlveolar Bone Loss
dc.subjectAlveolar Process
dc.subjectAnimals
dc.subjectBone Density
dc.subjectCalcium
dc.subjectCell Count
dc.subjectConnective Tissue
dc.subjectCyclosporine
dc.subjectDisease Models, Animal
dc.subjectEpithelium
dc.subjectGingiva
dc.subjectGingival Overgrowth
dc.subjectHomeostasis
dc.subjectImmunosuppressive Agents
dc.subjectInjections, Subcutaneous
dc.subjectMale
dc.subjectOsteoclasts
dc.subjectPeriodontium
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.titleEffects of long-term cyclosporin therapy on the periodontium of ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes2640929291808415
unesp.author.orcid0000-0003-2376-1024[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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