Effect of hexadecyltrimethylammonium bromide-based microemulsions on the rate of decomposition of the beta-lactam antibiotic cephaclor

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dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.authorScarpa, Maria Virgínia
dc.contributor.authorChaimovich, Hernan
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:09Z
dc.date.available2014-05-20T15:22:09Z
dc.date.issued1997-05-01
dc.description.abstractMicroemulsions of hexadecyltrimethylammonium bromide (HTAB)/n-butanol/hexadecane/water catalyze the intramolecular degradation of cephaclor. The rate increase is a sensitive function of the microemulsion volume fraction and salt concentration. The effects of microemulsions, analyzed quantitatively using a pseudophase ion-exchange model, assumed that the extent of ion dissociation from the microemulsions varies with volume fraction. Comparison of micellar and microemulsion effects on the same reaction shows that microemulsions are less effective catalysts. Acceleration decreased significantly by increasing the relative proportion of n-butanol ratio in microemulsions and by addition of n-butanol in HTAB micelles. Comparison of the activation parameters of the reaction in aqueous solution, microemulsions, and micelles suggests that catalysis by both aggregates is driven mainly by entropic contributions.en
dc.description.affiliationDepto. de Farmacos e Medicamentos Faculdade de Cie. de Farmaceuticas UNESP, Caixa Postal 331, CEP 14801-902, Araraquara, SP
dc.description.affiliationDepartamento de Bioquímica Instituto de Química USP, Caixa Postal 26077, CEP 05599-970, São Paulo, SP
dc.description.affiliationUnespDepto. de Farmacos e Medicamentos Faculdade de Cie. de Farmaceuticas UNESP, Caixa Postal 331, CEP 14801-902, Araraquara, SP
dc.format.extent616-620
dc.identifierhttp://dx.doi.org/10.1021/js9602599
dc.identifier.citationJournal of Pharmaceutical Sciences. Washington: Amer Pharmaceutical Assn, v. 86, n. 5, p. 616-620, 1997.
dc.identifier.doi10.1021/js9602599
dc.identifier.issn0022-3549
dc.identifier.lattes9114495952533044
dc.identifier.lattes4930795298045665
dc.identifier.scopus2-s2.0-0030974139
dc.identifier.urihttp://hdl.handle.net/11449/130652
dc.identifier.wosWOS:A1997WX10100015
dc.language.isoeng
dc.publisherAmer Pharmaceutical Assn
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.relation.ispartofjcr3.075
dc.relation.ispartofsjr0,984
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectButanol
dc.subjectCefaclor
dc.subjectCetrimide
dc.subjectHexadecane
dc.subjectDissociation
dc.subjectDrug decomposition
dc.subjectDrug degradation
dc.subjectDrug solubility
dc.subjectEntropy
dc.subjectIon exchange
dc.subjectMicroemulsion
dc.subjectMolecular dynamics
dc.subjectCatalysis
dc.subjectCefaclor
dc.subjectCephalosporins
dc.subjectCetrimonium Compounds
dc.subjectEmulsions
dc.subjectKinetics
dc.subjectThermodynamics
dc.titleEffect of hexadecyltrimethylammonium bromide-based microemulsions on the rate of decomposition of the beta-lactam antibiotic cephacloren
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderAmer Pharmaceutical Assn
unesp.advisor.lattes4930795298045665
unesp.author.lattes9114495952533044[1]
unesp.author.orcid0000-0002-0107-9940[1]
unesp.author.orcid0000-0001-9380-2157[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR