Study on the susceptibility of Enterococcus faecalis from infectious processes to ciprofloxacin and vancomycin

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dc.contributor.authorGenaro, A. [UNESP]
dc.contributor.authorCunha, M. L. R. S. [UNESP]
dc.contributor.authorLopes, C. A. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-07-14T10:39:03Z
dc.date.available2021-07-14T10:39:03Z
dc.date.issued2005-09
dc.description.abstractEnterococcus faecalis is considered a pathogen responsible for hospital infections and, due to its frequent multi-resistant profile, has caused preoccupations among many medical authorities. The objective of this study was to determine the antimicrobial susceptibility of 74 strains isolated from blood cultures and purulent secretions to vancomycin and ciprofloxacin through the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) by using the Microdilution test. The results showed a greater efficacy of vancomycin compared to ciprofloxacin (98.6% of the strains were inhibited by vancomycin at lower concentrations: 0.06 - 1 µg/ml). However, in the MBC analysis 73% of the strains showed a MBC of vancomycin only at high concentrations (equal to or higher than 64 µg/ml). For ciprofloxacin, the strains showed a broad sensitivity with MICs and MBCs distributed along all the MIC classes. Results also revealed a probability that some strains are tolerant to vancomycin, which indicates the need of other tests to confirm this characteristic.en
dc.description.affiliationUniversidade Estadual Paulista, Imaging Diagnosis, Botucatu School
dc.description.affiliationUniversidade Estadual Paulista, Institute of Biosciences
dc.description.affiliationUnespUniversidade Estadual Paulista, Imaging Diagnosis, Botucatu School
dc.description.affiliationUnespUniversidade Estadual Paulista, Institute of Biosciences
dc.format.extent252-260
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992005000300004
dc.identifier.citationJournal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 3, p. 252-260, 2005.
dc.identifier.doi10.1590/S1678-91992005000300004
dc.identifier.fileS1678-91992005000300004.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992005000300004
dc.identifier.urihttp://hdl.handle.net/11449/212380
dc.language.isoeng
dc.publisherCentro de Estudos de Venenos e Animais Peçonhentos
dc.relation.ispartofJournal of Venomous Animals and Toxins including Tropical Diseases
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectEnterococcus faecalisen
dc.subjectvancomycinen
dc.subjectciprofloxacinen
dc.subjectresistanceen
dc.subjectspontaneous mutationen
dc.titleStudy on the susceptibility of Enterococcus faecalis from infectious processes to ciprofloxacin and vancomycinen
dc.typeArtigo

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