Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils

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dc.contributor.authorSilva, João Paulo Assis
dc.contributor.authorRamos, Jordana Gomes
dc.contributor.authorCampos, Mônica Sousa
dc.contributor.authorda Silva Lima, Danilo
dc.contributor.authorde Azevedo Brito, Pedro Vale
dc.contributor.authorMendes, Elizabeth Pereira
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.authorBiancardi, Manoel Francisco
dc.contributor.authorGhedini, Paulo César
dc.contributor.authorSantos, Fernanda Cristina Alcantara
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:19:15Z
dc.date.available2019-10-06T16:19:15Z
dc.date.issued2019-04-01
dc.description.abstractThis study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. The results demonstrated that exposure to both types of bisphenol caused no changes in testosterone or estradiol serum levels. Morphologically, the effects of BPS and BPA on female prostates were similar and included changes in prostatic tissue compartments, glandular hyperplasia, AR and ERα up-regulation and increased cell proliferation. In males, BPS and BPA promoted differential effects, since the prostate presented morphological changes and proliferative disorders that were more pronounced in the BPS group. Therefore, this study demonstrates that BPS caused endocrine disruption in the prostate of male and female gerbils.en
dc.description.affiliationDepartment of Histology Embryology and Cell Biology Laboratory of Microscopy Applied to Reproduction Institute of Biological Sciences Federal University of Goiás
dc.description.affiliationDepartment of Physiological Sciences Institute of Biological Sciences Federal University of Goiás
dc.description.affiliationDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP Rua Cristóvão Colombo, 2265
dc.description.affiliationDepartment of Pharmacology Institute of Biological Sciences Federal University of Goiás
dc.description.affiliationUnespDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP Rua Cristóvão Colombo, 2265
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Goiás
dc.format.extent83-92
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2019.02.009
dc.identifier.citationReproductive Toxicology, v. 85, p. 83-92.
dc.identifier.doi10.1016/j.reprotox.2019.02.009
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-85062231264
dc.identifier.urihttp://hdl.handle.net/11449/188788
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAndrogen receptor
dc.subjectEndocrine-disrupting chemicals
dc.subjectEstrogen receptor
dc.subjectMorphology
dc.subjectReproduction
dc.titleBisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbilsen
dc.typeArtigo
unesp.author.orcid0000-0002-2184-4611[6]
unesp.author.orcid0000-0002-0970-4288[7]

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