Clinical outcome in chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation: The experience of the Bone Marrow Transplantation Unit of FUNFARME/BRAZIL using FISH

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dc.contributor.authorVendrame-Goloni, C. B. [UNESP]
dc.contributor.authorCarvalho-Salles, A. B.
dc.contributor.authorRuiz, M. A.
dc.contributor.authorRicci, O.
dc.contributor.authorVarella-Garcia, M.
dc.contributor.authorFett-Conte, A. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFundação Faculdade Regional de Medicina de São José do Rio Preto
dc.contributor.institutionUniversity of Colorado Comprehensive Cancer Center
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.date.accessioned2014-05-27T11:23:37Z
dc.date.available2014-05-27T11:23:37Z
dc.date.issued2008-07-30
dc.description.abstractInvestigation of the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in chronic myeloid leukemia patients is essential to predict prognosis and survival. In 20 patients treated at the Bone Marrow Transplantation Unit of São José do Rio Preto (São Paulo, Brazil), we used fluorescence in situ hybridization (FISH) to investigate the frequency of cells with BCR/ABL rearrangement at diagnosis and at distinct intervals after allo-HSCT until complete cytogenetic remission (CCR). We investigated the disease-free survival, overall survival in 3 years and transplant-related mortality rates, too. Bone marrow samples were collected at 1, 2, 3, 4, 6, 12, and 24 months after transplantation and additional intervals as necessary. Success rate of the FISH analyses was 100%. CCR was achieved in 75% of the patients, within on average of 3.9 months; 45% patients showed CCR within 60 days after HSCT. After 3 years of the allo-HSCT, overall survival rate was 60%, disease-free survival was 50% and the transplant-related mortality rate was 40%. The study demonstrated that the BCR-ABL FISH assay is useful for follow-up of chronic myeloid leukemia patients after HSCT and that the clinical outcome parameters in our patient cohort were similar to those described for other bone marrow transplantation units. ©FUNPEC-RP.en
dc.description.affiliationDepartamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, São José do Rio Preto, SP
dc.description.affiliationHemocentro Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, SP
dc.description.affiliationUnidade de Transplante de Medula Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, SP
dc.description.affiliationUniversity of Colorado Comprehensive Cancer Center, Denver, CO
dc.description.affiliationDepartamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP
dc.description.affiliationUnespDepartamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, São José do Rio Preto, SP
dc.format.extent417-423
dc.identifierhttp://dx.doi.org/10.4238/vol7-2gmr396
dc.identifier.citationGenetics and Molecular Research, v. 7, n. 2, p. 417-423, 2008.
dc.identifier.doi10.4238/vol7-2gmr396
dc.identifier.file2-s2.0-47949111183.pdf
dc.identifier.issn1676-5680
dc.identifier.scopus2-s2.0-47949111183
dc.identifier.urihttp://hdl.handle.net/11449/70495
dc.language.isoeng
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBCR-ABL fusion
dc.subjectChronic myelogenous leukemia
dc.subjectCytogenetic remission
dc.subjectDisease-free survival
dc.subjectFluorescence in situ hybridization
dc.subjectStem cell transplantation
dc.subjectBCR ABL protein
dc.subjectadolescent
dc.subjectadult
dc.subjectallogeneic hematopoietic stem cell transplantation
dc.subjectbone marrow
dc.subjectBrazil
dc.subjectcancer mortality
dc.subjectcancer regression
dc.subjectchronic myeloid leukemia
dc.subjectclinical article
dc.subjectdisease free survival
dc.subjectfluorescence in situ hybridization
dc.subjectgene rearrangement
dc.subjecthospital department
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectoverall survival
dc.subjectsurvival rate
dc.subjectsurvival time
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBone Marrow Transplantation
dc.subjectDisease-Free Survival
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectHospital Departments
dc.subjectHumans
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectLeukemia, Myelogenous, Chronic, BCR-ABL Positive
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectSurvival Rate
dc.subjectTransplantation, Homologous
dc.subjectTreatment Outcome
dc.titleClinical outcome in chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation: The experience of the Bone Marrow Transplantation Unit of FUNFARME/BRAZIL using FISHen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/5
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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