Applications of invertebrate animal models to dimorphic fungal infections

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dc.contributor.authorSingulani, Junya L. [UNESP]
dc.contributor.authorScorzoni, Liliana [UNESP]
dc.contributor.authorde Oliveira, Haroldo C. [UNESP]
dc.contributor.authorMarcos, Caroline M. [UNESP]
dc.contributor.authorAssato, Patricia A. [UNESP]
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.authorMendes-Giannini, Maria José S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:57:32Z
dc.date.available2019-10-06T16:57:32Z
dc.date.issued2018-01-01
dc.description.abstractDimorphic fungi can be found in the yeast form during infection and as hyphae in the environment and are responsible for a large number of infections worldwide. Invertebrate animals have been shown to be convenient models in the study of fungal infections. These models have the advantages of being low cost, have no ethical issues, and an ease of experimentation, time-efficiency, and the possibility of using a large number of animals per experiment compared to mammalian models. Invertebrate animal models such as Galleria mellonella, Caenorhabditis elegans, and Acanthamoeba castellanii have been used to study dimorphic fungal infections in the context of virulence, innate immune response, and the efficacy and toxicity of antifungal agents. In this review, we first summarize the features of these models. In this aspect, the growth temperature, genome sequence, availability of different strains, and body characteristics should be considered in the model choice. Finally, we discuss the contribution and advances of these models, with respect to dimorphic fungi Paracoccidioides spp., Histoplasma capsulatum, Blastomyces dermatitidis, Sporothrix spp., and Talaromyces marneffei (Penicillium marneffei).en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationInstitute of Science and Technology São José dos Campos São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Science and Technology São José dos Campos São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2015/14023-8
dc.description.sponsorshipIdFAPESP: 2016/17048-4
dc.description.sponsorshipIdFAPESP: 2017/06658-9
dc.description.sponsorshipIdCNPq: 403586/2012-7
dc.identifierhttp://dx.doi.org/10.3390/jof4040118
dc.identifier.citationJournal of Fungi, v. 4, n. 4, 2018.
dc.identifier.doi10.3390/jof4040118
dc.identifier.issn2309-608X
dc.identifier.scopus2-s2.0-85058036571
dc.identifier.urihttp://hdl.handle.net/11449/189952
dc.language.isoeng
dc.relation.ispartofJournal of Fungi
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAcanthamoeba castellanii
dc.subjectAntifungal
dc.subjectCaenorhabditis elegans
dc.subjectDimorphic fungi
dc.subjectGalleria mellonella
dc.subjectHost-pathogen interactions
dc.subjectInnate immunity
dc.subjectVirulence
dc.titleApplications of invertebrate animal models to dimorphic fungal infectionsen
dc.typeResenha
unesp.author.lattes3716273524139678[6]
unesp.author.orcid0000-0002-2115-8988[6]

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Artigos - Análises Clínicas - FCFAR