5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice

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dc.contributor.authorNunes-de-Souza, Vanessa
dc.contributor.authorNunes-de-Souza, Ricardo Luiz [UNESP]
dc.contributor.authorRodgers, Robert John
dc.contributor.authorCanto-de-Souza, Azair
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Leeds
dc.date.accessioned2014-05-20T13:25:01Z
dc.date.available2014-05-20T13:25:01Z
dc.date.issued2008-02-11
dc.description.abstractIt is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT) plays a dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical locus of action. Thus, whereas stimulation of 5-HT1A or 5-HT2 receptors in the limbic forebrain (amygdala, hippocampus) enhances anxiety-like responding in rodents, activation of corresponding receptor populations in the midbrain periaqueductal grey (PAG) more often than not reduce anxiety-like behaviour. The present study specifically concerns the anxiety-modulating influence of 5-HT2 receptors within the mouse PAG. Experiment 1 assessed the effects of intra-PAG infusions of the 5-HT2B/2C receptor agonist mCPP (0, 0.03, 0.1 or 0.3 nmol/0.1 mu l) on the behaviour of mice exposed to the elevated plus-maze. As mCPP acts preferentially at 5-HT2B and 5-HT2C receptors, Experiment 2 investigated its effects in animals pretreated with ketanserin, a preferential 5-HT2A/2C receptor antagonist. In both cases, test sessions were videotaped and subsequently, scored for anxiety-like behaviour (e.g., percentage of open arm entries and percentage of open arm time) as well as general locomotor activity (closed arm entries). The results of Experiment I showed that mCPP microinfusions (0.03 and 0.1 nmol) into the PAG of mice decreased behavioural indices of anxiety without significantly altering general activity measures. In Experiment 2, the anxiolytic-like profile of intra-PAG mCPP (0.03 nmol) was substantially attenuated by intra-PAG pretreatment with an intrinsically inactive dose of the preferential 5-HT2A/2C receptor antagonist, ketanserin (10 nmol/0.1 mu l). Together, these data suggest that 5HT(2C) receptor populations within the midbrain PAG play an inhibitory role in plus-maze anxiety in mice. (C) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Psychol, BR-13565905 São Carlos, SP, Brazil
dc.description.affiliationUNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Leeds, Inst Psychol Sci, Behav Neurosci Lab, Leeds LS2 9JT, W Yorkshire, England
dc.description.affiliationUnespUNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.format.extent72-79
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2007.08.030
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 187, n. 1, p. 72-79, 2008.
dc.identifier.doi10.1016/j.bbr.2007.08.030
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/11449/7913
dc.identifier.wosWOS:000252629900010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.relation.ispartofjcr3.173
dc.relation.ispartofsjr1,413
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectanxietyen
dc.subjectelevated plus-mazeen
dc.subject5-HT2 receptorsen
dc.subjectmCPPen
dc.subjectketanserinen
dc.subjectPAGen
dc.subjectmiceen
dc.title5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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