Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease

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dc.contributor.authorRocha, Thiara Barcelos [UNESP]
dc.contributor.authorGarate, Ana Lorena Sousa De Vasconcelos [UNESP]
dc.contributor.authorBeraldo, Rodrigo Fedatto [UNESP]
dc.contributor.authorLanças, Sean Hideo Shirata [UNESP]
dc.contributor.authorLeite, Fábio Vicente [UNESP]
dc.contributor.authorQuera, Rodrigo
dc.contributor.authorBarros, Jaqueline Ribeiro [UNESP]
dc.contributor.authorBaima, Julio Pinheiro [UNESP]
dc.contributor.authorSaad-Hossne, Rogerio [UNESP]
dc.contributor.authorSassaki, Ligia Yukie [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionClinica Universidad de Los Andes
dc.date.accessioned2022-05-01T09:31:07Z
dc.date.available2022-05-01T09:31:07Z
dc.date.issued2021-01-01
dc.description.abstractCutaneous involvement is one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD). More commonly, pyoderma gangrenosum and erythema nodosum are noted, but psoriasis, aphthous stomatitis, Sweet's syndrome, and vasculitis may also occur. Leukocytoclastic vasculitis (LCV) is a rare cutaneous manifestation, characterized by the appearance of palpable purpura, urticaria, and ulcer-necrotic lesions predominantly in the lower extremities that improve with immunosuppressive therapy. In this case, we report a patient with CD and LCV. We also searched the literature on the diagnosis and treatment of LCV in patients with CD. Female, 31, presented with diarrhea containing mucus and blood, abdominal pain, arthralgia, and enanthematous plaques and ulcers with a hematinic background in the lower extremities. The results of the colonoscopy were compatible with CD and skin biopsy showed signs of LCV. Systemic autoimmune disease and primary vasculitis were ruled out. The patient received treatment with a systemic corticosteroid and the skin lesions improved. Outpatient treatment with antitumor necrosis factor therapy was initiated to promote skin healing and IBD clinical remission. As LCV is a rare manifestation of IBD, it is necessary to distinguish this dermatopathy from other systemic vasculitis. The engagement of a multidisciplinary team is essential for the correct diagnosis and management.en
dc.description.affiliationSão Paulo State University (Unesp) Medical School
dc.description.affiliationClinica Universidad de Los Andes
dc.description.affiliationUnespSão Paulo State University (Unesp) Medical School
dc.format.extent825-831
dc.identifierhttp://dx.doi.org/10.1159/000519003
dc.identifier.citationCase Reports in Gastroenterology, p. 825-831.
dc.identifier.doi10.1159/000519003
dc.identifier.issn1662-0631
dc.identifier.scopus2-s2.0-85116828807
dc.identifier.urihttp://hdl.handle.net/11449/233652
dc.language.isoeng
dc.relation.ispartofCase Reports in Gastroenterology
dc.sourceScopus
dc.subjectCase report
dc.subjectCrohn's disease
dc.subjectExtraintestinal manifestation
dc.subjectInflammatory bowel disease
dc.subjectLeukocytoclastic vasculitis
dc.titleLeukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Diseaseen
dc.typeArtigo

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