Early light reduction for preventing retinopathy of prematurity in very low birth weight infants

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dc.contributor.authorJorge, Eliane Chaves [UNESP]
dc.contributor.authorJorge, Edson Nacib [UNESP]
dc.contributor.authorDib, Regina Paolucci El [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:35Z
dc.date.available2014-12-03T13:10:35Z
dc.date.issued2013-01-01
dc.description.abstractBackgroundRetinopathy of prematurity (ROP) is a complex condition of the developing retinal blood vessels and is one of the leading causes of preventable childhood blindness. Several risk factors for ROP have been studied over the past 50 years. Among them, general immaturity (low birth weight and low gestational age) and prolonged oxygen therapy have been consistently related to disease onset. However, it is understood that the progression of the disease is multifactorial and may be associated with others risk factors, such as multiple gestation, apnoea, intracranial haemorrhage, anaemia, sepsis, prolonged mechanical ventilation, multiple transfusions and light exposure. Furthermore, the precise role of these individual factors in the development of the disease has not yet been well established.ObjectivesTo determine whether the reduction of early environmental light exposure reduces the incidence of retinopathy of prematurity (ROP) or poor ROP outcomes among very low birth weight infants.Search methodsWe searched the following databases: the Cochrane Neonatal Group Specialised Register, CENTRAL (The Cochrane Library), MEDLINE, EMBASE, CINAHL, HealthSTAR, Science Citation Index Database, CANCERLIT, the Oxford Database of Perinatal Trials and www.clinicaltrials.gov. We also searched previous reviews including cross-references, abstracts, conference and symposia proceedings, and contacted expert informants. This search was updated in October 2012.Selection criteriaRandomised or quasi-randomised controlled trials that reduced light exposure to premature infants within the first seven days following birth were considered for this review. We also considered cluster-randomised controlled trials.Data collection and analysisData on clinical outcomes including any acute ROP and poor ROP outcome were extracted by both review authors independently and consensus reached. We conducted data analysis according to the standards of the Cochrane Neonatal Review Group.Main resultsData from four randomised trials with a total of 897 participants failed to show any reduction in acute ROP or poor ROP outcome with the reduction of ambient light to premature infants' retinas. The overall methodological quality of the included studies was about evenly split between those in which the classification was unclear and those in which the studies were categorised as low risk of bias. There was no report on the secondary outcomes considered in this review: quality of life measures; and time of exposure to oxygen.Authors' conclusionsThe evidence shows that bright light is not the cause of retinopathy of prematurity and that the reduction of exposure of the retinas of premature infants to light has no effect on the incidence of the disease.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Anaesthesiol, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Anaesthesiol, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.sponsorshipUniversity of Rochester, NY, USA
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA
dc.description.sponsorshipIdEunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USAHHSN275201100016C
dc.format.extent31
dc.identifierhttp://dx.doi.org/10.1002/14651858.CD000122.pub2
dc.identifier.citationCochrane Database Of Systematic Reviews. Hoboken: Wiley-blackwell, n. 8, 31 p., 2013.
dc.identifier.doi10.1002/14651858.CD000122.pub2
dc.identifier.issn1469-493X
dc.identifier.lattes0260120486355934
dc.identifier.lattes6692227903300380
dc.identifier.orcid0000-0003-3121-440X
dc.identifier.orcid0000-0002-4081-803X
dc.identifier.orcid0000-0002-9362-1505
dc.identifier.urihttp://hdl.handle.net/11449/112286
dc.identifier.wosWOS:000323928600002
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofCochrane Database of Systematic Reviews
dc.relation.ispartofjcr6.754
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectLightingen
dc.subjectInfant, Newbornen
dc.subjectInfant, Prematureen
dc.subjectInfant, Very Low Birth Weighten
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectRetinopathy of Prematurity [prevention & control]en
dc.subjectHumansen
dc.titleEarly light reduction for preventing retinopathy of prematurity in very low birth weight infantsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes0260120486355934[1]
unesp.author.lattes6692227903300380[2]
unesp.author.orcid0000-0002-4081-803X[3]
unesp.author.orcid0000-0003-3121-440X[2]
unesp.author.orcid0000-0002-4081-803X[3]
unesp.author.orcid0000-0002-9362-1505[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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