Exposure to crack cocaine causes adverse effects on marine mussels Perna perna

dc.contributor.authorMaranho, L. A.
dc.contributor.authorFontes, M. K.
dc.contributor.authorKamimura, A. S. S.
dc.contributor.authorNobre, C. R.
dc.contributor.authorMoreno, B. B.
dc.contributor.authorPusceddu, F. H.
dc.contributor.authorCortez, F. S.
dc.contributor.authorLebre, D. T.
dc.contributor.authorMarques, J. R.
dc.contributor.authorAbessa, D. M. S. [UNESP]
dc.contributor.authorRibeiro, D. A.
dc.contributor.authorPereira, C. D. S.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Santa Cecilia
dc.contributor.institutionCIETEC IPEN
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:42:18Z
dc.date.available2018-11-26T17:42:18Z
dc.date.issued2017-10-15
dc.description.abstractOur study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perm. For this purpose, fertilization rate, embryo-larval development, lysosomal membrane stability and DNA strand breaks were assessed. Effect concentrations in gametes and in larval development were found after 1 h (IC50 = 23.53 mg.L-1) and 48 h (IC50 = 16.31 mg.L-1),respectively. The highest tested concentration showing no acute toxicity (NOEC) was 10 mg.L-1, while the lowest observed effect concentration (LOEC) was 20 mg.L-1. NOEC concerning embryo-larval development was 0.625 mg.L-1, while the LOEC was 1.25 mg.L-1. Cyto-genotoxic effects were evidenced in mussels exposed to crack cocaine concentrations ranging from 5 to 500 mu g.L-1. Our results report the first data on effects of an illicit drug to marine organisms and should encourage further ecotoxicological studies of these contaminants of emerging concern in coastal ecosystems.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Mar, Rua Dr Carvalho Mendonga 144, BR-11070102 Santos, Brazil
dc.description.affiliationUniv Santa Cecilia, Lab Ecotoxicol, Rua Oswaldo Cruz 266, BR-11045907 Santos, Brazil
dc.description.affiliationCIETEC IPEN, CEMSA Ctr Espectrometria Massas Aplicada, Ave Prof Lineu Prestes 2242,Salas 112 & 113, BR-05508000 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Campus Litoral Paulista, Inst Biociencias, Infante Dom Henrique S-N, BR-11330900 Sao Vicente, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, Av Ana Costa 95, BR-11060001 Santos, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Campus Litoral Paulista, Inst Biociencias, Infante Dom Henrique S-N, BR-11330900 Sao Vicente, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2015/17329-0
dc.description.sponsorshipIdCNPq: 402931/2015-7
dc.format.extent410-414
dc.identifierhttp://dx.doi.org/10.1016/j.marpolbul.2017.08.043
dc.identifier.citationMarine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 123, n. 1-2, p. 410-414, 2017.
dc.identifier.doi10.1016/j.marpolbul.2017.08.043
dc.identifier.fileWOS000415776600061.pdf
dc.identifier.issn0025-326X
dc.identifier.urihttp://hdl.handle.net/11449/163503
dc.identifier.wosWOS:000415776600061
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMarine Pollution Bulletin
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCrack cocaine
dc.subjectBioassays
dc.subjectCyto-genotoxicity
dc.subjectMarine organism
dc.titleExposure to crack cocaine causes adverse effects on marine mussels Perna pernaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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