Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats

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dc.contributor.authorOliveira, Lucienne C. [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorRafacho, Bruna P. M. [UNESP]
dc.contributor.authorDuarte, Daniella R. [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:23Z
dc.date.available2014-05-20T13:33:23Z
dc.date.issued2011-02-01
dc.description.abstractObjective Our objective was to test the hypothesis that retinoic acid supplementation could attenuate ventricular remodelling induced by tobacco smoke exposure in rats.Methods and results Wistar rats were allocated into three groups: control (C, n = 8); exposed to tobacco smoke (ETS, n = 9); exposed to tobacco smoke and all-trans-retinoic acid (ETS-RA, n = 9). After two months, cardiac function and geometry were assessed by echocardiography, and geometry changes were confirmed by morphometric analysis. Data are expressed as mean +/- SD or medians (including the lower quartile and upper quartile). ETS showed higher normalized left ventricular diastolic diameters than groups C and ETS-RA (C = 18.4 +/- 3.57 mm/kg, ETS = 23.0 +/- 1.8, ETS-RA = 19.5 +/- 0.99; P < 0.05) and systolic diameters (C = 8.25 +/- 2.16 mm/kg, ETS = 11.5 +/- 1.31, ETS-RA = 8.25 +/- 0.71 mm/kg; P < 0.05). ETS showed reduced ejection fraction (C = 91 +/- 2.0, ETS = 87 +/- 3.0, ETS-RA = 92 +/- 3.0; P < 0.05) and fractional shortening (C = 55.8 +/- 4.41 %, ETS = 49.7 +/- 4.43 %, ETS-RA = 57.6 +/- 5.15 %; P = 0.01) compared to C and ETS-RA. ETS had increased myocyte cross-sectional area (C = 294 +/- 21 mm2, ETS = 352 +/- 44, ETS-RA = 310 +/- 35; P < 0.05) compared to C and ETS-RA. Considering all variables, there were no differences between groups C and ETS-RA.Conclusion Retinoic acid prevented ventricular remodelling induced by tobacco smoke exposure.en
dc.description.affiliationUNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.identifierhttp://dx.doi.org/10.2143/AC.66.1.2064960
dc.identifier.citationActa Cardiologica. Brussels: Acta Cardiologica, v. 66, n. 1, p. 3-7, 2011.
dc.identifier.doi10.2143/AC.66.1.2064960
dc.identifier.issn0001-5385
dc.identifier.lattes6309835137998766
dc.identifier.lattes6990977122340795
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.urihttp://hdl.handle.net/11449/11431
dc.identifier.wosWOS:000287980400002
dc.language.isoeng
dc.publisherActa Cardiologica
dc.relation.ispartofActa Cardiologica
dc.relation.ispartofjcr0.876
dc.relation.ispartofsjr0,404
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectRemodellingen
dc.subjectheart failureen
dc.subjectmyocardial hypertrophyen
dc.subjectsmokingen
dc.titleRetinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in ratsen
dc.typeArtigo
dcterms.rightsHolderActa Cardiologica
unesp.author.lattes5016839015394547[9]
unesp.author.lattes6309835137998766
unesp.author.lattes6990977122340795
unesp.author.lattes1213140801402647[2]
unesp.author.lattes7438704034471673
unesp.author.orcid0000-0001-8825-6980[4]
unesp.author.orcid0000-0003-4412-1990[8]
unesp.author.orcid0000-0002-5980-4367[3]
unesp.author.orcid0000-0002-5843-6232[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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