Effect of Bauhinia forficata extract in diabetic pregnant rats: maternal repercussions

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dc.contributor.authorVolpato, Gustavo Tadeu [UNESP]
dc.contributor.authorVolpato, G. T.
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorAguilar, R.
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSch Med Marilia
dc.date.accessioned2014-05-20T13:35:04Z
dc.date.available2014-05-20T13:35:04Z
dc.date.issued2004-02-01
dc.description.abstractBauhinia forficata, commonly known as paw-of-cow, is widely used in Brazil folk medicine for the treatment of Diabetes mellitus. The purposes of present study were to determine the repercussions of diabetes on the defense system against oxidative stress in pregnant female rats and to characterize the influence of the treatment with Bauhinia forficata extract on the antioxidant system, glycemic control, hepatic glycogen, cholesterol, triglycerides, total proteins and lipids. Virgin female Wistar rats were injected with 40 mg/kg streptozotocin (STZ) before mating. Oral administration of an aqueous extract of Bauhinia forficata leaves was given to non-diabetic and diabetic pregnant rats in 3 doses: 500 mg/kg from 0 to 4(th) day of pregnancy, 600 mg/kg from 5(th) to 14(th) day and 1000 mg/kg from 15(th) to 20(th) day. All the females were killed on the day 21 of pregnancy. A maternal blood sample was collected by venous puncture and the maternal liver was removed for biochemical measurement. The diabetic pregnant rats presented hyperglycemia, hyperlipemia, bypertriglyceridemia, hypercholesterolemia, hyperuricemia, decreased determinations of reduced glutathione (GSH) and superoxide dismutase (SOD). Treatment with B. forficata extract did not interfere in the albumin, total protein and lipid, triglyceride, cholesterol and SOD determinations. Increased hepatic glycogen, decreased uric acid concentration and increased GSH activity was observed. This last fact suggests that the plant may have some action on antioxidant defense system. However, the demonstration of the active component present in B. forficata responsible for its antioxidant effect and the increase in hepatic glycogen deserve further investigation.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Ginecol Obstet & Mastol, Dac Med, Sch Med,Expt Lab Obstet, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSch Med Marilia, Discipline Human Embryol, São Paulo, SP, Brazil
dc.description.affiliationSch Med Marilia, Discipline Biochem, São Paulo, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Ginecol Obstet & Mastol, Dac Med, Sch Med,Expt Lab Obstet, BR-18618000 Botucatu, SP, Brazil
dc.format.extent196-201
dc.identifierhttp://dx.doi.org/10.1078/0944-7113-00348
dc.identifier.citationPhytomedicine. Jena: Urban & Fischer Verlag, v. 11, n. 2-3, p. 196-201, 2004.
dc.identifier.doi10.1078/0944-7113-00348
dc.identifier.issn0944-7113
dc.identifier.lattes0679387622604743
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/12028
dc.identifier.wosWOS:000220762700016
dc.language.isoeng
dc.publisherUrban & Fischer Verlag
dc.relation.ispartofPhytomedicine
dc.relation.ispartofjcr3.610
dc.relation.ispartofsjr1,087
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBauhinia forficatapt
dc.subjectantioxidant systempt
dc.subjectmedicinal plantpt
dc.subjectdiabetespt
dc.subjectpregnancypt
dc.subjectoxidative stresspt
dc.titleEffect of Bauhinia forficata extract in diabetic pregnant rats: maternal repercussionsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderUrban & Fischer Verlag
unesp.author.lattes0679387622604743
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0003-4761-4336[3]
unesp.author.orcid0000-0002-9227-832X[5]
unesp.author.orcid0000-0002-4753-3264[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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