Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity

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dc.contributor.authorShiraishi, Flavio Gobbis [UNESP]
dc.contributor.authorBelik, Fernanda Stringuetta [UNESP]
dc.contributor.authorOliveira e Silva, Viviana Rugolo [UNESP]
dc.contributor.authorMartin, Luis Cuadrado [UNESP]
dc.contributor.authorHueb, João Carlos [UNESP]
dc.contributor.authorGoncalves, Renato de Souza [UNESP]
dc.contributor.authorCaramori, Jacqueline Socorro Costa Teixeira [UNESP]
dc.contributor.authorBarretti, Pasqual [UNESP]
dc.contributor.authorSilva Franco, Roberto Jorge da [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:28Z
dc.date.available2014-05-20T13:33:28Z
dc.date.issued2012-01-01
dc.description.abstractThe persistent inflammatory state is common in diabetes and chronic kidney disease (CKD). These patients present exercise intolerance and increased arterial stiffness. Long-term aerobic exercise has been associated with better arterial compliance, antidiabetic and antiinflammatory benefits. We assessed the hypothesis that in patients with diabetes and CKD, better aerobic capacity is associated with less inflammatory state and arterial stiffness. Thirty-nine CKD patients (17 in hemodialysis) were evaluated. According to CKD etiology two patient groups were obtained: group of diabetics (GD) was formed by 11 patients and nondiabetics (GND) formed by 28 patients. Central blood pressure and arterial stiffness were evaluated by Sphygmocor device. Carotida intima-media thickness (CA-IMT) was evaluated by ultrasonography. Aerobic capacity was measured by estimated VO(2)max according to treadmill test by Bruce protocol. The GD showed a higher frequency of C-reactive protein above laboratory cutoff (P = 0.044), higher frequency of male gender, and a non significant higher value of VO(2)max (P = 0.099). The CA-IMT was similar. Only better aerobic capacity was associated with lower frequency of high C-reactive protein when adjusted to diabetes and gender in a logistic regression model. In conclusion, aerobic capacity was associated with inflammatory state, in CKD patients, independently of diabetes presence.en
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Cardiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Cardiol, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1155/2012/750286
dc.identifier.citationExperimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 6, 2012.
dc.identifier.doi10.1155/2012/750286
dc.identifier.fileWOS000303731000001.pdf
dc.identifier.issn1687-5214
dc.identifier.lattes5496411983893479
dc.identifier.lattes7095933557855151
dc.identifier.lattes4923203168446615
dc.identifier.orcid0000-0003-4979-4836
dc.identifier.urihttp://hdl.handle.net/11449/11472
dc.identifier.wosWOS:000303731000001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofExperimental Diabetes Research
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleInflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacityen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes5496411983893479[8]
unesp.author.lattes7095933557855151
unesp.author.lattes4923203168446615
unesp.author.orcid0000-0003-4979-4836[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Clínica Médica - FMB