Mother-to-child transmission and gestational syphilis: Spatial-temporal epidemiology and demographics in a Brazilian region

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dc.contributor.authorSouza, Joyce Marinho de [UNESP]
dc.contributor.authorGiuffrida, Rogerio
dc.contributor.authorMarques Ramos, Ana Paula
dc.contributor.authorMorceli, Glilciane
dc.contributor.authorCoelho, Camila H.
dc.contributor.authorPimenta Rodrigues, Marcus Vinicius
dc.contributor.institutionUniv Oeste Paulista
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNIAID
dc.date.accessioned2019-10-04T12:42:51Z
dc.date.available2019-10-04T12:42:51Z
dc.date.issued2019-02-01
dc.description.abstractSyphilis is a Sexually Transmitted Infection (IST) with significant importance to public health, due to its impact during pregnancy (Gestational SyphilisGS); especially because syphilis can affect fetus and neonates' development (mother-to-child transmissionMTCT of syphilis), by increasing susceptibility to abortion, premature birth, skeletal malformations, meningitis and pneumonia. Measures to control and eliminate MTCT of syphilis have failed on the last few years in Brazil and this research aimed to identify the seasonality of notified cases of syphilis in a region of SAo Paulo state. The studied region, Pontal do Paranapanema, comprises 32 cities located in the West of SAo Paulo state, in Brazil. Data collected from the National System of Aggravations and Notification (SINAN) website was used to calculate the incidence rate of GS and MTCT. The incidence rate of GS was acquired dividing number of cases by number of women in each municipality and MTCT using number of live births in each year (from 2007 to 2013) in each municipality. This result was then, standardized multiplying incidence rate by 10,000 and expressed as incidence/10,000 women or live births, for GS and MTCT, respectively. To identify possible endemic/epidemic periods, a control diagram was performed using the standard deviation (SD) of incidence rate. Thematic maps representing the spatial distribution of incidence rates were constructed using a Geographic Information System software (GIS, based on cartographic vector available on the Brazilian Institute of Geography and Statistics (IBGE) website. Eighty cases of GS and 61 cases of MTCT were notified in the studied region. An increase of GS notification was detected in the Pontal do Paranapanema in 2011 followed by an increase in number of MTCT cases in the subsequent year, suggesting inefficacy in the treatment during gestational period. Most of those cases were reported on February and November which suggested seasonality for this IST in the region. The control diagram, based on the inputs collected from SINAN, showed no endemic period; however, the most susceptible month to happen an endemic event of GS and MTCT was February. Our study provided a new methodology to understand the syphilis dynamics as a potential tool to improve the success of future measures to control and possibly eliminate MTCT of syphilis. Author summary Syphilis is a sexually transmitted infection that can be transmitted to child during pregnancy, or postpartum, by an infected mother. Syphilis in children can interfere in the development and, in some cases, may lead to death. We analyzed cases of syphilis during pregnancy and mother-to-child transmission of syphilis from 2007 to 2013 occurred in a Brazilian region. We used a public online website provided by the Brazilian government to obtain information about cases, generate map locations and design a transmission pattern in the region. During the period investigated, we identified 80 cases of syphilis in pregnant woman and 61 related to mother-to-child transmission, both notified mainly during Summer (from November to February). Children infection might be related to incorrect treatment of mother and the partner. Not only the mother must be treated but the partner as well, otherwise women may be infected during pregnancy, transmitting syphilis to fetus. This study may help in the establishment of measures to control and eliminate mother-to-child transmission of syphilis.en
dc.description.affiliationUniv Oeste Paulista, Fac Ciencias Saude, Biomed, Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Lab Biol Mol Microrganismos, Londrina, PR, Brazil
dc.description.affiliationUniv Oeste Paulista, Programa Posgrad Meio Ambiente & Desenvolvimento, Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Oeste Paulista, Programa Posgrad Ciencia Anim, Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Oeste Paulista, Ciencias Saude, Presidente Prudente, SP, Brazil
dc.description.affiliationNIAID, Lab Malaria Immunol & Vaccinol, DIR, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
dc.description.affiliationUnespUniv Estadual Paulista, Lab Biol Mol Microrganismos, Londrina, PR, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade do Oeste Paulista (UNOESTE)
dc.description.sponsorshipIntramural Research Program of the National Institute for Allergy and Infectious Diseases, NIH
dc.description.sponsorshipIdFAPESP: 2016/16465-0
dc.format.extent16
dc.identifierhttp://dx.doi.org/10.1371/journal.pntd.0007122
dc.identifier.citationPlos Neglected Tropical Diseases. San Francisco: Public Library Science, v. 13, n. 2, 16 p., 2019.
dc.identifier.doi10.1371/journal.pntd.0007122
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/11449/186212
dc.identifier.wosWOS:000459970700032
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos Neglected Tropical Diseases
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleMother-to-child transmission and gestational syphilis: Spatial-temporal epidemiology and demographics in a Brazilian regionen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
unesp.author.orcid0000-0001-6633-2903[3]
unesp.author.orcid0000-0002-3997-369X[6]

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Artigos - Planejamento, Urbanismo e Ambiente - FCT